Short, simple and convergent syntheses of the title compounds have been accomplished with good overall yields using a Montmorillonite K-10 clay catalyzed Friedel-Crafts alkylation reaction in 'dry media' as the key step.
A. L. KHURANA and A. M. UNRAU. Can. J. Chem. 53,3011 (1975). Lithium aluminum hydride reduction of alkyl substituted isoxazoles gave a variety of products. The major constituent was identified (i.r., n.m.r., m.s.) as hydroxyethylaziridine. Specifically, reduction of 3,4,5-trimethylisoxazole gave as the major product 2,3-dirnethyl-3-Bhydroxyethylaziridine. Two of the more prominent minor products were identified as 2,3-dimethyl-3-ethylaziridine and 4-amino-3-methyl-2-pentanol. The corresponding products were identified when 3,5-dimethylisoxazole was reduced with LAH.
Terpenes Terpenes U 0200 Microwave Assisted Facile Synthesis of Elvirol, Curcuphenol and Sesquichamaenol Using Montmorillonite K-10 Clay in Dry Media. -The other two title compounds are prepared in a very similar fashion to elvirol (V). -(SINGH*, V.; KHURANA, A.; KAUR, I.; SAPEHIYIA, V.; KAD, G. L.; SINGH, J.; J.
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