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Cancer remains to be a major global healthcare burden as 18.1 million new cases and 96 million death occurred 2018 on the basis of report from the international agency for research on cancer Breast cancer is the most common cancer diagnosed in women causing the highest morbidity. Ipomoea carnea leaf extracts have been used as a chemotherapeutic agent due to their antioxidant, anti-inflammatory, anti-bacterial, and anti-tumor effect. The aim of the study is to evaluate the proapoptotic potential of Ipomoea carnea leaf extract on breast cancer cell lines (MCF-7). The proapoptotic potential of Ipomoea carnea leaf extract was assessed using an MTT assay. The cell morphological changes in Ipomoea carnea leaf extract-treated cells were observed under a phase-contrast microscope. The proapoptotic effect of Ipomoea carnea leaf extract was examined using DAPI staining. The MTT assay results showed a significant reduction in the viability of breast cancer cells after treatment with different concentrations of Ipomoea carnea leaf extract (5-80 µg/ml) for 24h. We observed the inhibitory concentration at 20 μg/ml. Morphological changes such as reduction in the number of cells, cell shrinkage, and cytoplasmic membrane blebbing indicate the hallmark features of apoptosis were observed in Ipomoea carnea leaf extract-treated cells. DAPI staining results showed that apoptotic nuclei are stained intensely, fragmented, and have condensation chromatin in treated cells. Therefore it can be concluded that Ipomoea carnea leaf extracts have a pro-apoptotic potential in the breast cell cancer lines (MCF-7). Keywords: Ipomoea carnea, Breast cancer, MCF-7, Apoptosis

The current COVID-19 epidemic caused by the new SARS-CoV-2 has severely harmed global healthcare (severe acute respiratory syndrome coronavirus). COVID-19's pulmonary and cardiovascular effects have been known from its inception, but its causes, mechanisms, and neuropath logical consequences remain unknown. Our research focused on neurological problems in COVID-19 patients, as well as probable SARS-CoV-2 infection routes like hematogenous, direct/neuronal, lymphatic tissue, cerebrospinal fluid, or infiltration by infected immune cells. Late December 2019 in Wuhan, China, a mysterious viral pneumonia struck. The disease was caused by a new corona virus. Corona virus infection spread rapidly from person to person in 2019. The WHO has called it a global public health emergency (WHO). Activation of NF-B in SARS-CoV-2 infection may be linked to immune cell pathogenicity, cytokine storms, and multi-organ failure. COVID-19's inhibition of the NF-B signaling pathway shows promising therapeutically. Inhibiting IKK phosphorylation, a critical downstream consequence of the NF-B signaling cascade, reduces COVID-19 levels. All three disorders have been linked to COVID-19 gene mutations. This study provides a biological basis for future research on COVID-19-related neurological disease. W

To present study was carried out to investigate antiulcer activity of Ethanolic extract of Momordica dioica fruits in pylorus ligatated and  Cold stress induced ulceration in the wistar rats. Pylorus ligation induced ulcer is one of the most widely used methods for studying the effect of drug on gastric secretion. Effect of distilled water in pylorus ligation has caused the accumulation of gastric sectretion and decreased the pH. Ranitidine and Ethanolic extracts of Momordica dioica significantly decreased the gastric volume, total acidity, free acidity, ulcer score, number of ulcer and ulcer index and raise the pH (shown in graph. 1, 2, 3, 4, 5, 6,).Similar studies support our results. Ethanolic extract of Momordica dioica  at a dose of (400mg/kg. p.o) showed  significant inhibition of ulcerative lesion by 46.33% and 54.66%, respectively, as compared to the control value The Ethanol extract of Momordica dioica fruits possess significant antiulcer properties in a dose dependent manner.