Background: Preeclampsia is present in 2% -5% of pregnancies and is the major cause of perinatal and maternal morbidity and mortality. Doppler studies of the uterine artery in the first trimester is a major screening parameter for determining preeclampsia in women. Doppler is a non invasive and highly sensitive method to determine the fetoplacental circulation. The parameters assessed in Doppler are a high resistance index, persistent uterine artery notching and a high pulsatility index. Aims and objectives: To assess the role of uterine artery Doppler at 12 to 16 weeks of gestation for the prediction of preeclampsia. Material and methods: Hundred antenatal women of 12 to 16 weeks of singleton pregnancy were selected for the study. After an informed consent and detailed examination, the women were subjected to transvaginal ultrasound. Doppler assessment of uterine circulation and the various uterine artery indices were measured. The women were further followed up clinically for development of preeclampsia. Results: Out of 100 women, 31 patients developed preeclampsia. In our study 37% of the women had Bilateral uterine artery notching, mean RI was 0.5612, PI was 0.9104 at 12-16 weeks.Our study showed a statistically significant association between uterine artery diastolic notching, raised RI, PI and the development of preeclampsia as compared to non preeclamptic women. In our study, uterine artery notching at 12-16 weeks gestation has a sensitivity of 65.30%, specificity of 84.60%, PPV of 54.60% and NPV of 70.50%. When notch and RI >0.65 were taken together, the sensitivity changed to 82.60%, specificity to 85.40%, PPV to 37.60% and NPV to 98.40%.
Conclusion:The uterine artery notching, high Resistance Index and Pulsatility Index in uterine artery Doppler waveform at 12-16 weeks has shown as best screening test for early prediction of preeclampsia.
In the fusion of 16O+72,76Ge→ 88,92Zr reactions the significance of structural and bulk properties of projectile-target combination is investigated at energies across the Coulomb barrier. For the purpose, the role of distinct Skyrme interactions (SIII, SKM*, SGII, RATP, T6, SkP), in conjunction with different surface diffuseness parameter (a=0.45-0.99) and nuclear charge radii i.e. iso-spin dependent and iso-spin independent are examined for the studied reaction. These geometrical parameters have their straight effect on the interaction barrier and the fusion excitation function. Thus, the sensitivity of fusion barrier and the cross sections in the sub barrier region of 88,92Zr Compound systems is carefully explored. The estimations of fusion cross sections are done in the framework of Wong formula and are compared with the respective experimental data. The observations implies that SKM* Skyrme interaction in which nuclear radius derived from polynomial fit gives relatively better result than the considered iso-spin dependent and independent nuclear charge radii. Further, the behaviour in the cross sections of Zr isotopes is investigated in terms of surface diffuseness parameter, which depicts that surface width is higher for neutron rich nucleus and lower for the neutron deficient one.
Antiphospholipid syndrome is associated with a hallmark of Obstetric complications including recurrent miscarriage, early delivery, oligohydramnios, prematurity, intrauterine growth restriction, fetal distress, fetal or neonatal thrombosis, pre-eclampsia/eclampsia, HELLP syndrome, arterial or venous thrombosis and placental insufficiency. Antiphospholipid antibodies promote activation of endothelial cells, monocytes and platelets, causing an overproduction of tissue factor and thromboxane A2. These factors lead to a hypercoagable state leading to various obstetric complications. The aim of this study was to evaluate the prevalence of anti-phospholipid antibodies in patients with RPL and to evaluate the relation of antibody positivity with other parameters.
Epidermoid inclusion cysts are the most common types of simple dermal epithelial benign lesions, presenting as wellencapsulated subepidermal mobile nodules. They arise on hair-bearing areas but vulva is a rare site. We here report clinical and ultrasonography (USG) findings of a big epidermal nontraumatic inclusion epidermoid cyst at the vulva which was excised and histopathological examination confirmed diagnosis of epidermoid inclusion cyst without any dysplasia.
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