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(Weibel, 1963), but the application to general studies of the microcirculation has not been reported to date. A further advantage of this method is that it does not require the independent estimation of vessel diameter, which is difficult to determine in excised tissue sections because of the collapse and oblique sectioning of the majority of vessels (own unpublished work).We describe the vascular structure of a large series of cutaneous melanomas in terms of L,, S, and V, derived from three independent morphometric measurements. The prognostic value of tumour vascularity is assessed both independently and in relation to other clinical and histological features. Patients and methodsThe study was based on the computerised melanoma registry at Frenchay Hospital (Briggs, 1985 (Holthofer et al., 1982).The prognostic information was not known to the observer at the time of morphometric measurement. Vascular morphometryThe UAE-I stained slides were examined by light microscopy at a magnification of x 200. Three anatomically distinct areas of each section were identified for the measurement of vascular parameters as described by Srivastava et al. (1986): in the margin of normal papillary dermis adjacent to the tumour, within the tumour itself and at the junction between the tumour and underlying tissue.Correspondence: P. Carnochan.

[structure: see text]. The NK-1 receptor antagonist 1 has been prepared in seven steps from phenylglycine methyl ester. The key steps are a double ring closing metathesis reaction of tetraene 7 to prepare spirocycle 6 and a reductive Heck reaction to introduce the aryl moiety. This latter reaction discriminates the olefins of compound 6 and proceeds in a highly regio- and stereoselective manner.

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