Rats subjected to prolonged macrophage depletion showed an increased prevalence of senescent RBC in the circulation due to their impaired clearance by macrophages. Hence, these animals provide a model system in which mechanisms of RBC aging can be delineated. They also showed impaired erythropoiesis, presumably related to a reduction in BM macrophages and increased production of proinflammatory cytokines by residual activated marrow macrophages and other cells.
Haematological abnormalities because of Cl2MDP-CL-induced macrophage depletion are potentiated in aged rats in which the BM regenerative potential of the erythroid lineage as well as the clearance function of the spleen appear compromised. Thus, in aged rats, macrophage dysfunction is likely to interfere with erythroid homeostasis particularly during haemopoietic stress.
THERAPEUTIC FRONTIERS AND MOLECULAR PROGNOSTIC INDICATORS IN ONCOLOGY use of G-CSF, many questions remain unanswered including optimal doses and schedules in order to maximize its efficacy-and minimize costs. We started this study to evaluate the correlation between hematological parameters and the response to G-CSF treatment of neutropenic patients treated with standard dose chemotherapy.
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