Impact analysis is the identification of the potential consequences of a change, or estimating what needs to be modified to accomplish a change, including related costs and schedule estimates. In this work, we distinguish between two kinds of concerns related to impact analysis: (1) business-specific concerns, those related to stakeholders interested in checking if other business rules are impacted by the change and also need to be modified; and (2) software-specific concerns, those related to stakeholders interested in the impacted software artifacts that need to be modified. Several traceability techniques have been studied and none of them supported impact analysis that dealt with business-specific concerns with reasonable values of precision and recall for the discovered impacts. Our research work aims to support businessspecific concerns during impact analysis, by proposing and evaluating a traceability technique that resorts on a new traceability model defined over business rules, with expected precision and recall values of 100%.
Methylmalonic acidemia was first described in 1967 and represents an autosomal recessive disease originating from a disorder of propionate metabolism. Although rare, it is one of the most frequent inborn errors of organic acid metabolism. The disease can manifest itself in the first days of life or have late onset in childhood. The therapy is based on protein restriction and carnitine supplementation. The present study reports a case of an infant who was seen at the hospitals emergency room with vomiting, dehydration, fever, adynamia, hyporexia, hypotonia and hyporesponsiveness, and developmental delay. Started research for methylmalonic acidemia and confirmed diagnosis through laboratory tests. Therefore, it is important to have studies and research on rare genetic diseases so that medical professionals can update, diagnose and seek early treatment for such patients.
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