Brachytherapy with Iodine-125 seeds is an effective alternative treatment for early stage prostatic cancer, with good biochemical disease control rates and low to moderate toxicity. The best results were obtained in low and intermediate risk patients.
ObjectiveTo evaluate the relationship between two year PSA nadir (PSAn) after brachytherapy
and biochemical recurrence rates in prostate cancer patients.Materials and MethodsIn the period from January 1998 to August 2007, 120 patients were treated with
iodine-125 brachytherapy alone. The results analysis was based on the definition
of biochemical recurrence according to the Phoenix Consensus.ResultsBiochemical control was observed in 86 patients (71.7%), and biochemical
recurrence, in 34 (28.3%). Mean PSAn was 0.53 ng/ml. The mean follow-up was 98
months. The patients were divided into two groups: group 1, with two year PSAn
< 0.5 ng/ml after brachytherapy (74 patients; 61.7%), and group 2, with two
year PSAn ≥ 0.5 ng/ml after brachytherapy (46 patients; 38.3%). Group 1
presented biochemical recurrence in 15 patients (20.3%), and group 2, in 19
patients (43.2%) (p < 0.02). The analysis of biochemical
disease-free survival at seven years, stratified by the two groups, showed values
of 80% and 64% (p < 0.02), respectively.ConclusionLevels of two year PSAn ≥ 0.5 ng/ml after brachytherapy are strongly
correlated with a poor prognosis. This fact may help to identify patients at risk
for disease recurrence.
Objectives: To assess the incidence and clinical parameters that could influence migration of seeds in localized prostate cancer patients treated by stranded versus loose sources by Iodine-125 brachytherapy. Materials and Methods: 100 patients were treated from January/1998 until December/2006. Age, PSA, clinical stage, Gleason, prostate volume, number of seeds, activity of radioactive seeds, and dosimetric parameters, such as V 100 , V 150 and D 90 were evaluated. Results: Mean follow-up was 79 months (18 -120. CI 95%: 72 -85). Overall, 6 of 100 patients experienced seed migration. Seed migration was found in 4/50 (8%) patients using loose seeds and in 2/50 (4%) treated by stranded seeds. Mean value dosimetric parameters for stranded seeds were greater than those for loose seeds (V 100 (
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