To determine the clinicopathologic significance of Kikuchi-Fujimoto disease (KFD) and review the literature on this condition, we conducted a MEDLINE search of English-language articles published between 1972 and December 2003. KFD has a worldwide distribution, and Asiatic people have a higher prevalence. Its pathogenesis remains controversial. Patients are young and seek care because of acute tender, cervical lymphadenopathy and low-grade fever. Histologic findings include paracortical areas of coagulative necrosis with abundant karyorrhectic debris. Karyorrhectic foci consist of various types of histiocytes, plasmacytoid monocytes, immunoblasts, and small and large lymphocytes. There is an abundance of T cells with predominance of CD8+ over CD4+ T cells. Differential diagnosis includes lymphoma, lymphadenitis associated with systemic lupus erythematosus, and even adenocarcinoma. KFD is an uncommon, self-limited, and perhaps underdiagnosed process with an excellent prognosis. Accurate clinicopathologic recognition is crucial, particularly because KFD can be mistaken for malignant lymphoma.

Background Cutaneous reactions after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are poorly characterized. Objective To describe and classify cutaneous reactions after SARS-CoV-2 vaccination. Methods A nationwide Spanish cross-sectional study was conducted. We included patients with cutaneous reactions within 21 days of any dose of the approved vaccines at the time of the study. After a face-to-face visit with a dermatologist, information on cutaneous reactions was collected via an online professional

A B S T R A C T PurposePrimary care physicians (PCPs) constitute an appropriate target for new interventions and educational campaigns designed to increase skin cancer screening and prevention. The aim of this randomized study was to determine whether the adjunct of dermoscopy to the standard clinical examination improves the accuracy of PCPs to triage lesions suggestive of skin cancer. Patients and MethodsPCPs in Barcelona, Spain, and Naples, Italy, were given a 1-day training course in skin cancer detection and dermoscopic evaluation, and were randomly assigned to the dermoscopy evaluation arm or naked-eye evaluation arm. During a 16-month period, 73 physicians evaluated 2,522 patients with skin lesions who attended their clinics and scored individual lesions as benign or suggestive of skin cancer. All patients were re-evaluated by expert dermatologists at clinics for pigmented lesions. Referral accuracy of both PCP groups was calculated by their scores, which were compared to those tabulated for dermatologists. ResultsReferral sensitivity, specificity, and positive and negative predictive values were 54.1%, 71.3%, 11.3%, and 95.8%, respectively, in the naked-eye arm, and 79.2%, 71.8%, 16.1%, and 98.1%, respectively, in the dermoscopy arm. Significant differences were found in terms of sensitivity and negative predictive value (P ϭ .002 and P ϭ .004, respectively). Histopathologic examination of equivocal lesions revealed 23 malignant skin tumors missed by PCPs performing naked-eye observation and only six by PCPs using dermoscopy (P ϭ .002). ConclusionThe use of dermoscopy improves the ability of PCPs to triage lesions suggestive of skin cancer without increasing the number of unnecessary expert consultations. J Clin Oncol 24:1877-1882. © 2006 by American Society of Clinical Oncology INTRODUCTIONSkin cancer is the most common malignancy in whites and accounts for about one third of all cancers diagnosed per year.1 Melanoma is often lethal but can usually be cured if diagnosed early. Nonmelanoma skin cancer (including basal cell carcinoma [BCC] and squamous cell carcinoma [SCC]) is seldom lethal, but if advanced, can cause severe disfigurement. Early detection and treatment, therefore, is the best strategy to reduce mortality and morbidity associated with melanoma and nonmelanoma skin cancers, respectively.The clinical diagnosis of skin cancer is based on several morphologic features pertaining to the shape, elevation, surface, and color of the tumor. The simple morphologic features summarized by the asymmetry, border irregularity, color variegation, and diameter Ͼ 5 mm (ABCD) rule are currently widely used for diagnosing skin cancer, particularly melanoma.2 However, ABCD criteria achieve only 65% to 80% sensitivity. 3 The ABCD rule fails to recognize melanomas that are small (Ͻ 6 mm) 4 or that exhibit regular shape and homogeneous color. On the other hand, a variety of benign pigmented skin lesions mimic melanoma clinically, resulting in unnecessary excisions.For diagnosis of skin cancer, dermoscopy has be...

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