Not only are the generic products bioequivalent with the reference product, but also with each other.

The therapeutic options analysed for the base-case cohort can be considered cost-effective interventions for the Spanish healthcare framework. Sensitivity analysis estimated an acceptability threshold of the IL28B-guided strategy of patients younger than 60 years.

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Although mechanisms of price regulation and financing policy are different throughout the member States, most countries have introduced measures to reduce the increase in expenditure on medicines, with generic products being an important aspect since they are less expensive than innovating medicines.

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rs4962153 showed an association with cryptogenic stroke (Table 1). This association is interesting in view of the fact that prothrombotic variants have been suggested as risk factors for cryptogenic stroke [8], but there are no studies on ADAMTS13 in this subtype. We found no significant associations for any of the other IS subtypes. However, whether this is due to a subtype-specific effect of ADAMTS13 gene variation or a lack of statistical power in the smaller subgroups cannot be determined from these findings.In conclusion, three SNPs in the ADAMTS13 gene were found to be associated with IS in the present population of relatively young patients from western Sweden. The SNP rs4962153 showed significant associations with both overall ischemic stroke and the subtype cryptogenic stroke. To the best of our knowledge, this is the first study investigating ADAM-TS13 gene variants in a large cohort of patients with IS and in different subtypes of IS. Thus, further studies are needed in order to investigate whether the present finding can be replicated, and whether there are associations for other subtypes apart from cryptogenic stroke.

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