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Preventive care and telemedicine are expected to play an important role in reducing the impact of an increasingly aging global population while increasing the number of healthy years. Virtual coaching is a promising research area to support this process. This paper presents a user-centered virtual coach for older adults at home to promote active and healthy aging and independent living. It supports behavior change processes for improving on cognitive, physical, social interaction and nutrition areas using specific, measurable, achievable, relevant, and time-limited (SMART) goal plans, following the I-Change behavioral change model. Older adults select and personalize which goal plans to join from a catalog designed by domain experts. Intervention delivery adapts to user preferences and minimizes intrusiveness in the user’s daily living using a combination of a deterministic algorithm and incremental machine learning model. The home becomes an augmented reality environment, using a combination of projectors, cameras, microphones and support sensors, where common objects are used for projection and sensed. Older adults interact with this virtual coach in their home in a natural way using speech and body gestures on projected user interfaces with common objects at home. This paper presents the concept from the older adult and the caregiver perspectives. Then, it focuses on the older adult view, describing the tools and processes available to foster a positive behavior change process, including a discussion about the limitations of the current implementation.

Objective:The study aimed to characterize morphological changes of the retinal microvascular network during the progression of diabetic retinopathy. Methods:Publicly available retinal images captured by a digital fundus camera from DIARETDB1 and STARE databases were used. The retinal microvessels were segmented using the automatic method, and vascular network morphology was analyzed by fractal parametrization such as box-counting dimension, lacunarity, and multifractals. Results:The results of the analysis were affected by the ability of the segmentation method to include smaller vessels with more branching generations. In cases where the segmentation was more detailed and included a higher number of vessel branching generations, increased severity of diabetic retinopathy was associated with increased complexity of microvascular network as measured by box-counting and multifractal dimensions, and decreased gappiness of retinal microvascular network as measured by lacunarity parameter. This association was not observed if the segmentation method included only 3-4 vessel branching generations. Conclusions:Severe stages of diabetic retinopathy could be detected noninvasively by using high resolution fundus photography and automatic microvascular segmentation to the high number of branching generations, followed by fractal analysis parametrization. This approach could improve risk stratification for the development of microvascular complications, cardiovascular disease, and dementia in diabetes. K E Y W O R D Sdiabetic retinopathy, fractal analysis, lacunarity, microvascular network morphology, multifractals 2 of 12 | POPOVIC et al.

To date, the use of synthetic data generation techniques in the health and wellbeing domain has been mainly limited to research activities. Although several open source and commercial packages have been released, they have been oriented to generating synthetic data as a standalone data preparation process and not integrated into a broader analysis or experiment testing workflow. In this context, the VITALISE project is working to harmonize Living Lab research and data capture protocols and to provide controlled processing access to captured data to industrial and scientific communities. In this paper, we present the initial design and implementation of our synthetic data generation approach in the context of VITALISE Living Lab controlled data processing workflow, together with identified challenges and future developments. By uploading data captured from Living Labs, generating synthetic data from them, developing analysis locally with synthetic data, and then executing them remotely with real data, the utility of the proposed workflow has been validated. Results have shown that the presented workflow helps accelerate research on artificial intelligence, ensuring compliance with data protection laws. The presented approach has demonstrated how the adoption of state-of-the-art synthetic data generation techniques can be applied for real-world applications.

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