<p><strong>Introduction:</strong> In this study, we reviewed a clinical series composed by all malignant lung lesions submitted to computed tomographyguided percutaneous thermal radiofrequency ablation, in our hospital, a rather recent technique that has been gaining scientific recognition.<br /><strong>Material and Methods:</strong> For data purposes, all radiofrequency ablation and corresponding clinical records were retrospectively<br />analysed. A computed tomography scan was performed before and after each procedure to evaluate the tumour’s features, and at a second step to assess results and complications. The frequency of local recurrence and disease progression were determined based on imaging follow-up. Kaplan–Meier analysis was used to estimate survival. Univariate analysis recognized clinical and pathological factors affecting survival. These were also tested by multivariate analysis.<br /><strong>Results:</strong> A total of 28 malignant lung lesions, 20 primary and 8 metastatic, from 28 patients (78.6% male; mean age 62 ± 17 years old), were submitted to computed tomography-guided radiofrequency ablation between January 2004 and July 2010. Total necrosis was achieved in 74.1% of the lesions. Immediate radiofrequency ablation-related complications were observed in half of the procedures. Among major complications, death occurred in one patient only. Median overall survival was 43.0 months for a mean 2-years follow-up.<br />Median progression-free survival was 31.6 months. Lesion’s size smaller than 35 mm, stage III disease by the TNM classification and previous treatment attempts were significantly associated with better outcomes. Disease-related mortality was 46.4%.<br /><strong>Discussion: </strong>This procedure proved to be efficient to treat lung cancerous lesions, with a low-rate of major complications.<br /><strong>Conclusions:</strong> Computed tomography-guided percutaneous radiofrequency ablation is a minimally invasive procedure that appears to be valuable in the treatment of lung cancer lesions.<br /><strong>Keywords:</strong> Catheter Ablation; Lung Neoplasms; Tomography, X-Ray Computed.</p>