After 2 years of follow-up, LHM, as compared with pneumatic dilation, was not associated with superior rates of therapeutic success. (European Achalasia Trial Netherlands Trial Register number, NTR37, and Current Controlled Trials number, ISRCTN56304564.).

Regarding the various components of the metabolic syndrome, in patients with adrenal incidentalomas and SH, surgery is beneficial.

Objective: Few data are available regarding the need of steroid substitutive therapy after unilateral adrenalectomy for adrenal incidentaloma (AI). It is unknown whether, before surgery, the hypothalamic-pituitary-adrenal (HPA) axis secretion parameters can predict post-surgical hypocortisolism. Aim: This study aimed to evaluate whether, in AI patients undergoing unilateral adrenalectomy, postsurgical hypocortisolism could be predicted by the parameters of HPA axis function. Design: Prospective, multicenter. Methods: A total of 60 patients underwent surgical removal of AI (surgical indication: 29 subclinical hypercortisolism (SH); 31 AI dimension). Before surgery, SH was diagnosed in patients presenting at least three criteria out of urinary free cortisol (UFC) levelsO60 mg/24 h, cortisol after 1-mg dexamethasone suppression test (1 mg-DST)O3.0 mg/dl, ACTH levels!10 pg/ml, midnight serum cortisol (MSC)O5.4 mg/dl. Two months after surgery, HPA axis function was assessed by low dose ACTH stimulation test or insulin tolerance test when needed: 39 patients were affected (Group B) and 21 were not affected (Group A) with hypocortisolism. The accuracy in predicting hypocortisolism of pre-surgical HPA axis parameters or their combinations was evaluated. Results: The presence of O2 alterations among 1 mg-DSTO5.0 mg/dl, ACTH!10 pg/ml, elevated UFC and MSC has the highest odds ratio (OR) for predicting post-surgical hypocortisolism (OR 10.45, 95% confidence interval, PZ0.001). Post-surgical hypocortisolism was predicted with 100% probability by elevated UFC plus MSC levels, but not ruled out even in the presence of the normality of all HPA axis parameters. Conclusion: Post-surgical hypocortisolism cannot be pre-surgically ruled out. A steroid substitutive therapy is indicated after unilateral adrenalectomy for SH or size of the adenoma.European Journal of Endocrinology 162 91-99

The enteric nervous system of the lower esophageal sphincter area is impaired in patients with "idiopathic achalasia," and the abnormalities involve ICC and neurons in many patients. The triggering factors for these abnormalities are, however, still unknown.

Idiopathic achalasia is characterized by the absence of peristalsis secondary to loss of neurons in the myenteric plexus that hampers proper relaxation of the lower esophageal sphincter. Achalasia can be considered a multifactorial disorder as it occurs in related individuals and is associated with HLA class II genes, thereby suggesting genetic influence. We used microarray technology and advanced in-silico functional analyses to perform the first genome-wide expression profiling of mRNA in tissue samples from 12 achalasia and 5 control patients. It revealed 1,728 differentially expressed genes, of these, 837 (48.4%) were up-regulated in cases. In particular, genes participating to the smooth muscle contraction biological function were mostly up-regulated. Functional analysis revealed a significant enrichment of neuronal/muscular and neuronal/immunity processes. Upstream regulatory analysis of 180 genes involved in these processes suggested TLR4 and IL18 as critical key-players. Two functional gene networks were significantly over-represented: one involved in organ morphology, skeletal muscle system development and function, and neurological diseases, and the other participating in cell morphology, humoral immune response and cellular movement. These results highlight on pivotal genes that may play critical roles in neuronal/muscular and neuronal/immunity processes, and that may contribute to the onset and development of achalasia.

The ectopic or accessory liver lobe is an uncommon congenital anatomic abnormality. It is considered to be the outcome of an abnormal development of liver tissue during embryologic period. In some cases, it may be secondary to a trauma or a surgical operation. Literature reports only anecdotal cases; there are not series. The most common localization is the abdominal cavity, but very rarely it can also be found in the thoracic cavity. In most cases, preoperative correct diagnosis is very difficult because it is unlikely to consider this rare condition in course of differential diagnosis. Most cases are misdiagnosed, and patients undergo surgical intervention with suspect of lung lesion. Some times the intrathoracic accessory lobe is an intraoperative incidental finding. In this report, we present the case of a young female patient who underwent surgical treatment for a suspect pulmonary lesion that at histological examination resulted to be an intrathoracic accessory hepatic lobe.

Esophageal cancer is the eight most common cancer in the world and surgical resection remains the gold standard not only in providing the optimal chance for cure but also the best palliation for dysphagia.Esophagectomy is a complex operation and is associated with significant morbidity and mortality that are

Whereas laparoscopic cholecystectomy represents the gold standard treatment for gallstones, there is no universal consensus on the optimal treatment of common bile duct (CBD) stones. The options available are various: preoperative or postoperative endoscopic retrograde cholangiography and sphincterotomy, laparoscopic transcystic CBD exploration, laparoscopic choledochotomy, and traditional open choledochotomy. A few reports describe intraoperative endoscopic clearance of the CBD. The choice of one of these methods depends on the timing of the detection of CBD stones with regard to the cholecystectomy, the expertise of the surgeon, the technology available, and the wishes of the patient. In the surgical department of the "Ospedale Casa Sollievo della Sofferenza," a large referral medical center in Italy, we perform an intraoperative endoscopic sphincterotomy in the presence of findings suspicious for CBD stones in the course of a laparoscopic cholecystectomy. The procedure is readily available thanks to the nearby presence of a skilled endoscopist and is greatly aided by the insertion of a transcystic guidewire, which makes the papilla easily identifiable by the endoscope for the spincterotomy. We have used the technique successfully in 43 of 45 patients over a 7-year period in an overall caseload of 1775 laparoscopic cholecystectomies, with no complications, minimal added operative time, and no added postoperative hospital stay. The technique allows us to completely and definitively manage CBD stones detected intraoperatively at the time of the performance of the laparoscopic cholecystectomy with no added discomfort to the patient.