Angelica sylvestris L. (Apiaceae) of the Isle of Skye (Scotland): chemical composition of essential oil from the aerial flowering partsAngelica is a large genus of plants belonging to Apiaceae family that includes about 100 species of biennial or perennial herbs. Several species of this genus are extensively used in various traditional medicines and, despite their content in toxic furanocoumarins, also as food. In the present study the chemical composition of the essential oil (EO) from aerial flowering parts of Angelica sylvestris L., a plant distributed in Europe, North and Central Asia, collected in the Isle of Skey (Scotland), was analyzed by GC and GC-MS. No one report has been previously published on this accession. The result showed the presence of large quantity of monoterpene hydrocarbons with limonene (51.89%), by far, as the most abundant component. Other metabolites present in lesser quantity were β-pinene (4.61%), α-pinene (3.54%), and thymol (3.33%). Considerations with respect all the other EOs of A. sylvestris taxa, studied so far, were carried out.
Heracleum sphondylium L. subsp. sphondylium (Apiaceae) of the Isle of Skye (Scotland): the chemical composition of essential oil from the flowering aerial parts Heracleum is a large genus of plants belonging to Apiaceae family that includes about 90 species of biennial or perennial herbs. Several species of this genus are extensively used in various traditional medicines and, despite their content in toxic furanocoumarins, also as food. In the present study the chemical composition of the essential oil (EO) from flowering aerial parts of Heracleum sphondylium L. subsp. sphondylium, a plant distributed in Europe and North-West Africa, collected in the Isle of Skey (Scotland), was analyzed by GC and GC-MS.No one report has been previously published on any British accession. The result showed the presence of large quantity of sesquiterpene hydrocarbons and aliphatic esters with bicyclogermacrene (31.6%) and octyl acetate (29.5%), by far, as the most abundant components. Considerations with respect all the other EOs of H. sphondylium taxa, studied so far, were carried out.
Chemical composition of the essential oil ofCyanus adscendens (Bartl.) Soják and C. orbelicus (Velen.) Soják growing wild in Bulgaria, and PCA analysis of genus Cyanus Mill. Cyanus Mill. genus, belonging to the Asteraceae family, includes more than fifty taxa, mainly growing in Central and Southern Europe, North Africa, Asia Minor, and the Caucasus. Previous investigations on Cyanus taxa have shown that they are rich source of flavonoids and phenolic compounds but, differently from species of genus Centaurea, almost devoid of sesquiterpene lactones.In the present study, the chemical composition of the essential oils from aerial parts of Cyanus adscendens (CA) and C. orbelicus (CO), collected in Bulgaria, and not previously investigated, was evaluated by GC-MS. The main components of CA were α-bergamotene (31.3%), (Z,Z,Z)-9,12,15-octadecatrien-1-ol (14.5%) and calarenepoxide (11.0%). Caryophyllene oxide (12.0%), together with αcadinol (10.9%) and spathulenol (8.8%), were recognized as the main constituent of C. orbelicus EO. Furthermore, a complete review on the composition of all essential oils of the Cyanus taxa studied so far has been inserted and cluster analysis (PCA) was carried out.
Phytochemical investigation and antitumor activity of coumarins from Sicilian accession of Ferulago nodosa (L.) Boiss. rootsFerulago nodosa (L.) Boiss. (Apiaceae) is a species occurring in the Balkan-Tyrrhenian area being present in Crete, Greece, Albania, and probably in Macedonia. From the roots of this accession of species, not previously investigated, four coumarins, grandivittin, aegelinol benzoate, felamidin and aegelinol, and two terpenoids, (2E)-3-methyl-4-[(3-methyl-1-oxo-2-buten-1yl)oxy]-2-butenoic acid and pressafonin-A, were isolated and spectroscopically characterized. The last one was never detected in Ferulago species. The evaluation of the anti-tumor effects of F. nodosa coumarins on colon cancer HCT116 cells showed only a modest effect on reduction of tumor cell viability. For aegelinol, the reduction of colon cancer cell viability already appears with 25 , while using 50 e 100 M doses of marnesin the residual viability amounted to 70% and 54%, respectively. This effect resulted more evident at higher doses of compounds (at 200M from 80% to 0%). The most effective compounds resulted coumarins lacking ester group.
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