Descriptions of two rare gastric neuroendocrin e tumors (carcinoids) of enterochromaf n (ECL) cells in CD-1 mice (2/50) from a 104-week oncogenicity study of a serotonergic/dopaminergi c compoun d are presented. These tumors were detected at necropsy and con rmed by histopathology in hematoxyli n and eosin-and Chromogranin A-stained slides. ECL cell counts of the glandular stomachs were determined by quantitative image analysis and did not reveal any hyperplasti c changes as possible predisposing lesions for carcinoid formation. To investigate the possibility of druginduced hypergastrinemi a as the cause of tumor formation of ECL cells, gastrin blood levels were measured after treating mice for 7 days with the test substance. In this study, Omeprazole, the positive control, raised gastrin levels, while the test material did not. It was concluded that these two tumors were an example of "late-life"-occurring, spontaneous neuroendocrin e tumors in the stomachs of aged CD-1 mice.
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