Background. Malignant cutaneous cylindroma is a rare tumor. It has been described in 26 cases, both in the solitary form and in the autosomal dominant inherited multiple tumor form. The authors present two new cases that occurred in one family with a history of multiple cylindromas. Methods. Clinical and histopathologic data of both tumors were compared with those of 26 other cases in the literature. Immunohistochemical examinations were performed. Results. The malignant tumors were distinguished from the benign lesions by rapid growth, long‐standing ulceration, or bleeding. Histopathologic examination showed a well‐differentiated carcinoma in one patient and a poorly differentiated tumor in the other. In the latter, lymph node metastasis developed, and the patient died 2.5 years later. Histopathologic criteria of malignancy included cell pleomorphism, frequent mitoses and loss of jigsaw pattern, peripheral palisading, hyaline sheaths, and dual cell population. Conclusions. These observations are in accord with those in the literature. Malignant cutaneous cylindroma developed more often in the multiple tumor form than in the single tumor form. Malignant cylindroma is an aggressive carcinoma with a tendency to local destructive growth and metastases.

Efficacy and safety of fluticasone propionate 0.005% ointment in the long-term maintenance treatment of children with atopic dermatitis: Differences between boys and girls?Atopic dermatitis (AD) affects 8.9-20.4% of those born after 1970 (1). Despite the introduction of topical immune modulators, topical corticosteroids and emollients are still the mainstay of drug therapy in AD. Although the history of topical corticosteroids in dermatology covers half a century and many trials, available clinical studies do not reflect the common clinical practice and the need for long-term treatment. As a consequence, there is no consensus as to the best treatment regimen. While mild AD can be managed with emollients and mild to moderately potent topical corticosteroids, treatment of moderate severe and severe AD requires more potent corticosteroids. However, bringing an acute episode of AD under control is only one aspect of Glazenburg EJ, Wolkerstorfer A, Gerretsen AL, Mulder PGH, Oranje AP. Efficacy and safety of fluticasone propionate 0.005% ointment in the long-term maintenance treatment of children with atopic dermatitis: Differences between boys and girls?

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