Under routine clinical conditions, treatment with low-dose 5-FU/SA effectively reduced AK lesions even during short treatment periods, while exhibiting good tolerability. These findings are in keeping with results obtained from a clinical phase III trial.
AK lesions on the hands and/or forearms were effectively treated with low-dose 5-FU/SA under routine conditions in dermatological practice and the treatment was well tolerated.
EinleitungTrockene Haut, die mit Rauigkeit, Sprödigkeit, Schuppung, Spannungsgefühl und in der Regel mit quälendem Juckreiz verbunden ist, stellt das Leitsymbol zahlreicher Dermatosen dar, wie atopisches Ekzem, chronisches Kontaktekzem
AbstractAn established commercial cream containing polidocanol and urea has been tested in double-blind, randomised clinical studies, in comparison with a new lotion formulation, that has been developed for extensive treatment of the whole body. The studies were carried out in 19 healthy volunteers and 30 atopic eczema patients with itching and dry skin. The results show that the cream and the lotion have very good skin tolerance, significantly increased skin moisture and skin lipids and have fastonset anti-itching efficacy. Both products are highly effective for the treatment of itching and dry skin of patients with atopic eczema.
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The efficacy and safety of a bath oil containing soya oil and anti-pruritic lauromacrogols have been demonstrated in experimental and clinical studies. In order to generate more efficacy and safety-related data on the day-to-day use in paediatric practice, a post-marketing surveillance study has been conducted. More than 3500 patients--the vast majority (61.4%) aged 0-4 years--were included in this investigation. Atopic eczema was diagnosed in 86.4% of the cases. The average duration of treatment was 42 days. The results confirm that the anti-pruritic bath oil is both well-tolerated and effective in treating dry and itchy skin diseases. The sum score of symptoms decreased during the treatment period from 7.21 to 2.71 mean score points. The physicians assessed the global efficacy in 89.4% of the cases as 'very good' or 'good'. Anti-pruritic properties of the combination were rated 'very good' or 'good' in 84.3%. The local tolerability was stated to be 'good' or 'very good' in 96.8% of the patients. In total, only 10 out of the 3566 patients, 0.28% respectively, experienced discomfort.Moreover, the physicians estimated that the bath oil therapy helped to reduce therapeutics like steroids in nearly 60% of patients. The potential to reduce use of external steroids and other specific therapeutics is also of particular relevance from a pharmacoeconomic point of view.
Under routine clinical conditions, treatment with low-dose 5-FU/SA effectively reduced AK lesions even during short treatment periods, while exhibiting good tolerability. These findings are in keeping with results obtained from a clinical phase III trial.
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