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SUMMARY In 23 patients (ages 44 to 81) presenting with syncope, vertigo, or transient amnesia, carotid sinus massage produced a significant bradycardia in association with symptoms.

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1 Indoramin is a new a-adrenoceptor blocking agent. We have evaluated the profile of blood pressure reduction over 24 h with intra-arterial ambulatory blood pressure monitoring by means of a double-blind placebo-controlled crossover trial. The effect on the heart rate was also recorded. 2 The blood pressure response to standardized procedures including supine rest, tilt, isometric and dynamic bicycle exercise were also recorded. 3 Indoramin caused a significant reduction of the ambulatory blood pressure during 16 h of the day for systolic pressures and 12 h for diastolic pressures.4 There was no evidence of postural hypotension or sustained reflex tachycardia. The absolute blood pressures were lowered during isometric and dynamic exercise.5 Indoramin was associated with a high incidence of side-effects; however if used in combination with other antihypertensive agents a lower dose might well be better tolerated.

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