In comparison to the formulations containing untreated carriers, the removal of carrier fines by wet decantation leads to a reduced in vitro deposition. This is possibly caused by an increase in the surface smoothness and an increase in the number of high energetic spots.
Purpose: Investigation of the crystallinity of salbutamol sulfate a model drug used in the dry powder inhalation formulation. Materials and Methods: Salbutamol sulfate was supplied kindly by Lindopharm (Hilden, Germany). Salbutamol sulfate was milled using an air jet milling process, the particle size and morphology were determined using laser diffraction and the scanning electron microscopy. The drug was subjected to conditioning through storage at 52.8% and 75% relative humidity for 24 h, 1 week, and 2 weeks, respectively. The drug crystallinity was investigated using differential scanning calorimetry (DSC), X-ray diffraction, and water vapor sorption techniques. Results and Discussion: Conditioning of salbutamol sulfate after micronization lowers the glass transition (Tg) temperature of the amorphous parts present at particle surface, which enhances particle mobility for more rearrangement associated with water expelling. This transformation may result in deviation from the original particle size obtained after milling out of respirable range. DSC and X-ray diffraction show no detectable amorphous drug since no detectable Tg observed. Alternatively, water vapor sorption shows a small amount of amorphous salbutamol sulfate at the particle surface, which recrystallizes at 52.8% relative humidity after approximately 2 weeks of conditioning. Conclusion: The amorphous regions can be generated in crystalline materials during processing. The level of amorphous materials can affect every step of pharmaceutical formulation, storage, and stability. However, quantification of low levels of amorphous content still poses considerable challenge. This study confirms that, the water vapor sorption technique is useful in the quantification of a small amount of drug amorphous content.
Promethazine hydrochloride tablets commercially available at Libyan market. It is use as antihistaminic tablet and strong seddative. This study aims to measure the quality of those promethazine tablets.Materials: Promethazine 25mg tablets purchased from pharma international company, Benghazi-Libya.Results: The hardness test shows a value of 6.76kg, the promethazine tablet with 0.401cm thickness (h) and 0.820cm in diameter (r) requires a force of 13.465kg/cm (T.s) to be broken. The results obtained comply with the British pharmacopeia1998. The tablet friability of 0.032% does not meet the standards. The tablets have weight uniformity of 209.3mg, which meets the pharmacopeia. Disintegration test shows that the tablets completely disintegrated after 1.84min. The content uniformity results were within a pharmacopeial limit. Additionally, the dissolution test results were out of the pharmacopeial range.Conclusion: The promethazine tablets deviate from some pharmacopeial tests, which emphasized the need of continuous investigations to the antihistaminic tablets at Libyan market.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.