Adverse effects of targeted drugs on normal tissues can predict the cancer response. Rash correlates with efficacy of erlotinib, cetuximab and gefitinib and onset of arterial hypertension with response to bevacizumab, sunitinib, axitinib and sorafenib, possible examples of 'Black Swan' events, unexpected scientific observations, as described by Karl Popper in 1935. The proposition is that our patients have individual intrinsic variants of cell growth control, important for tumor response and adverse effects on tumor-unrelated tissue. This means that the lack of predictive side effects in healthy tissue is linked with poor results of tumor therapy when tumor resistance is caused by mechanisms that protect all cells of that patient from the targeted drug effects.
The results of early conversion of war fractures by the application of AO osteosynthesis in A group (n = 32) of the injured, were compared with B group (n = 187) of injured, treated definitely with external fixator. There were statistical evaluations and X-ray observations of healing in both groups, as well as the appearances of the most frequent complications such as: Pintract infection, osteitis, pseudoarthrosis and reoperation. Statistically less significant appearance of complications in A group during 2nd and 6th month (p < 0.001) was observed. In 12th month of observation, these differences statistically disappeared. Healing observed by X-ray in 2nd, 6th and 12th month of observation were no statistically significant differences between the two observed groups.
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