INTRODUCTION: Recent trials have shown that the addition of procarbazine, lomustine, and vincristine (PCV) chemotherapy to radiotherapy (RT) improves survival in anaplastic oligodendroglioma. With improved survival, the quality of survival becomes pivotal. Because data regarding longterm functioning in anaplastic glioma patients are lacking, we evaluated cognitive functioning and health-related quality of life (HRQOL) in a cohort of Dutch and French long-term survivors from the European Organisation for Research and Treatment of Cancer (EORTC) trial 26951 on adjuvant PCV for anaplastic glioma. METHODS: Of the 28 Dutch patients and 9 French patients, 25 (89%) and 7 (78%), respectively, included in EORTC trial 26951 who were still alive agreed to participate. Cognitive functioning (assessed using neuropsychological tests for six cognitive domains) was compared with matched healthy controls. Patients' HRQOL (assessed with the EORTC QLQ-C30 and BN20 questionnaires) was compared with that of healthy controls, with the patients' own HRQOL 2.5 years following initial RT, and with the patient by proxy. Tumor histology, location, and recurrence; treatment; and the presence of epilepsy in the last year were recorded. RESULTS: The median survival time was 147 months. A total of 41% of patients did not have cognitive impairment, and 34% had severe impairment (≥ 4 domains affected). A total of 31% of patients were employed, 78% were independent in the activities of daily living. Patients' HRQOL was worse than controls' but was similar to 2.5 years after initial treatment. Treatment (in 35% of patients RT only, in 65% RT/PCV), histology and location were not correlated with cognition or HRQOL. Current epilepsy was associated with slower speed and poorer memory. Recent recurrence (13%) was associated with worse HRQOL. CONCLUSIONS: Cognitive functioning in longterm anaplastic glioma survivors is variable. However, most patients function independently. HRQOL is relatively stable during the course of the disease but is affected by recent recurrence. No effect of the addition of PCV to RT on cognition or on quality of survival could be identified in this patient group.
It has been documented that the incidence of inflammation along with oxidative stress in biological system leads to the development of age related complications. However, the mechanism exploring the conundrum of senescence with various sorts of health complications is still in obscure. Therefore, the present study was designed to evaluate the relation of serum paraoxonase (PON) with markers of systemic inflammation and lipid peroxidation in the blood samples of different age group subjects and to determine their relation in the prediction of cardiovascular disease risk. Marker of lipid peroxidation (malondialdehyde; MDA), serum paraoxonase, c-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were estimated in selected 90 healthy subjects by using standard methods. Out of 90 subjects, 60 individuals were categorized into two groups: Group I (40-55 years) and Group II (≥ 56 years) and statistically compared it with that of 30 younger controls (20-30 years). Marked depletion in serum PON activity was observed in Group I and II as compared to healthy controls whereas erythrocyte MDA levels were increased significantly (p<0.05) in Group I and II subjects. However, serum CRP levels were increased significantly (p<0.05) only in Group II subjects whereas ESR levels were altered insignificantly (p<0.01) in Group I and II subjects as compare to controls. In addition, PON activity was inversely correlated with marker of systemic inflammation and lipid peroxidation. Thus, assessment of serum paraoxonase activity incorporation with marker of systemic inflammation is a crucial step in early diagnosis of cardiovascular complications in elderly. Therefore, regular monitoring of cardiac markers and antioxidant rich diet should be adopted with senescence.
Objective: This study was aimed to assess the quality of life (QoL) of the subjects having congestive heart failure (HF) under different domains of life, such as physical, psychological, and social domains, and they started taking the standard care treatment. Methods: The questionnaire-based prospective study was designed to assess the effects of the HF in different domains of life such as social, psychological, physical, or mental. After getting consent from the subjects, health questionnaire was provided to a total of 60 subjects. Results: We found drastic improvements in 24% of total HF cases in terms of physical debility, whereas only 15% patients reported none of the complications during taking standard care therapy. Total 32.5% patients aware of the treatment took and to whom contact in an emergency. Psychological disturbances and life satisfaction were observed in 16.66% and 33.33% cases suffering from HF. Patient compliance means personal life, as well as medication adherence, was observed in only 53.33%. Conclusions: The results obtained from the responses given by the patients in the health questionnaires demonstrated that the HF patients’ needs awareness regarding the therapy precautions that improving the QoL of patients.
A comparative preliminary study on the extraction and phytochemical profile of methanolic extracts of the leave, stem and root of pennisetum pedicellatum Trin at three growth stages (i.e stage 1, stage 2, stage 3) was carried out. The extracts were analysed to determine the presence of phytochemicals in the plant. The study revealed the presence of alkaloids, flavonoids, saponins and steroids. Tanins were found only in the stems of the plants and steroids were found only in the leaves. The relevance of this difference in distribution is yet to be understood. More research is needed to explain this and other observations. Methanolic extraction of roots, stems and leaves of pennisetum pedicellatum indicated that leaves of stage 2 plants contain more phytochemicals (37.6g or 10.21%) as compared to all other plant parts and growth stages. The sample of stage 2 plants showed the least percentage yield (3.86%) as compared to all other parts and stages of growth.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.