Intracellular signaling pathways that converge on Smad 3 are used by both TGF-β and activin A, key cytokines implicated in the process of fibrogenesis. To determine the role of Smad 3 in allergen-induced airway remodeling, Smad 3-deficient and wild-type (WT) mice were sensitized to OVA and challenged by repetitive administration of OVA for 1 mo. Increased levels of activin A and increased numbers of peribronchial TGF-β1+ cells were detected in WT and Smad 3-deficient mice following repetitive OVA challenge. Smad 3-deficient mice challenged with OVA had significantly less peribronchial fibrosis (total lung collagen content and trichrome staining), reduced thickness of the peribronchial smooth muscle layer, and reduced epithelial mucus production compared with WT mice. As TGF-β and Smad 3 signaling are hypothesized to mediate differentiation of fibroblasts to myofibroblasts in vivo, we determined the number of peribronchial myofibroblasts (Col-1+ and α-smooth muscle actin+) as assessed by double-label immunofluorescence microscopy. Although the number of peribronchial myofibroblasts increased significantly in WT mice following OVA challenge, there was a significant reduction in the number of peribronchial myofibroblasts in OVA-challenged Smad 3-deficient mice. There was no difference in levels of eosinophilic airway inflammation or airway responsiveness in Smad 3-deficient compared with WT mice. These results suggest that Smad 3 signaling is required for allergen-induced airway remodeling, as well as allergen-induced accumulation of myofibroblasts in the airway. However, Smad 3 signaling does not contribute significantly to airway responsiveness.
Induction of immunologic tolerance is highly desirable in the treatment and prevention of allergy and other immune disease states in which the immune response to foreign or self antigens has become overactive. Indoleamine-2,3-dioxygenase (IDO), an enzyme classically known for its role in the tryptophan degradation pathway, has recently emerged as an important immunomodulator of T-cell function and inducer of tolerance. The induced expression of IDO by dendritic cells may suppress T-cell responses and promote tolerance either through direct effects on T cells (mediated by tryptophan depletion or tryptophan metabolites) or through effects of IDO on the dendritic cell. In addition to the potential role of IDO in promoting tolerance in pregnancy, transplantation, and autoimmunity, its role in modulating allergic responses has more recently been investigated, raising the possibility that IDO and its metabolites may be novel targets for immunomodulation in allergy and asthma.
With the judicious use of inhaled corticosteroids, β2 agonists, and leukotriene modifiers, most patients with asthma are easily controlled and managed. However, approximately 5% of asthmatics do not respond to standard therapy and are classified as "difficult to control." [1] Typically, these are patients who complain of symptoms interfering with daily living despite long-term treatment with inhaled corticosteroids in doses up to 2,000 μg daily. Many factors can contribute to poor response to conventional therapy, and especially for these patients, a systematic approach is needed to identify the underlying causes. First, the diagnosis of asthma and adherence to the medication regimen should be confirmed. Next, potential persisting exacerbating triggers need to be identified and addressed. Concomitant disorders should be discovered and treated. Lastly, the impact and implications of socioeconomic and psychological factors on disease control can be significant and should be acknowledged and discussed with the individual patient. Less conventional and novel strategies for treating corticosteroid-resistant asthma do exist. However, their use is based on small studies that do not meet evidence-based criteria; therefore, it is essential to sort through and address the above issues before reverting to other therapy.
The Coalition of Asian American Associations (CAAA) and Asian American Coalition for Education (AACE), two small but vocal groups of Asian Americans, have argued against affirmative action practices. One of their more prominent claims is that Asian American applicants who are not accepted and do not attend their first-choice colleges face a multitude of negative consequences, a claim that has become the impetus for the current U.S. Department of Justice’s investigation into the college admissions process at a number of universities. This study empirically tests the claims made by CAAA and AACE with particular attention to the differences in Asian American student outcomes, relative to their college admissions and choice decisions. Our findings indicate a limited, if any, statistical difference between Asian American groups that attend differing choice institutions.
Diagnosis of ACABS should primarily be made based on the clinical history. Other modalities provide useful information in select cases.
Purpose Operating since 1994, the UCSD Moores Cancer Center’s Asian Grocery Store-Based Cancer Education Program (the Program) is a proven and sustainable strategy for disseminating cancer and poison control information to Asian and Pacific Islander (API) communities. This paper describes the process taken to identify health topics that can be readily addressed within the Program’s infrastructure, and reports results of the pilot testing of the educational module that was developed by following that process. Methods The development of each new module is guided by the Health Belief Model and the Tipping Point Model. The process starts with the selection of a health topic demonstrating pressing need and treatment options in the API community. Then, using the Pareto Principle, reasonably modifiable risk factors are chosen to be addressed in the module. “Sticky messaging” for the modifiable risk factors is developed to package the health information as memorable and transmissible calls-to-action. Finally, grocery store outreaches were used to pilot test the new module to assess its effectiveness at facilitating health care information to API community members. Results By adhering to the steps described in this paper, the authors were able to: (1) select liver cancer as a pressing API health issue that could be positively impacted by the Program; (2) identify reasonably modifiable risk factors for the chosen health issue; (3) generate compelling call-to-action messages to decrease risk of exposure; and (4) demonstrate the cultural and linguistic alignment of the liver cancer control module. Conclusion The development and testing of new health education modules follow a methodical process guided by scientific principles. Understanding and employing the elements of an existing evidence-based and sustainable health education program can increase the likelihood of success in addressing the health needs of the API community.
Though protests on college campuses have captured public attention, far less consideration has been paid to Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). The Asian and Pacific Islander American (APIA) population has historically served on the front lines of the Asian American Movement during the Civil Rights Movement influencing the educational experiences of APIA students. While literature documents student activism from APIA students, they are portrayed as an apolitical group. The purpose of this article is to (re)conceptualize the term protest to capture the historical and contemporary forms of activism by researchers, policy makers, community organizers, and students throughout a decade that pushed a legislation forward to create the federal designation for AANAPISIs. We argue that the term protest is limiting in research. Instead, the term activism should be used in order to encapsulate the ways APIAs have been engaged socially and politically. Additionally, there exists a gap in educational literature discussing how the spatial politics of domination and resistance manifests in representational spaces-in this case institutional structures like AANAPISIs. Influenced by spatial politics and spatial theory we put forth a conceptual argument that the representational existence of AANAPISIs is a site of resistance that needs to be better understood, especially in the era of Trump where anti-immigration and racist rhetoric is ever-present, because of the ways APIAs continue to be racialized and (re)positioned in United States racial discourse and research.
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