Videos are often employed in medical cursus, yet few guidelines are available to help with their production. Mayer's cognitive theory of multimedia learning is the most cited evidence-based framework for improving pedagogical effectiveness of multimedia content. Based on this framework, we identified four workflow interventions to improve the effectiveness of video content in the context of medical education: (1) choosing appropriate content; (2) optimizing the voiceover; (3) optimizing the supporting visuals and (4) planning the shooting schedule in advance. Content creators should think about pedagogical effectiveness and aim to improve their work by applying evidence-based principles.
Introduction: Osteogenesis imperfecta (OI) is a collagen disorder associated with osseous, dental and tissue brittleness and abnormal bleeding in spite of normal coagulation profile(1). This is the first report of an OI patient with severe intra-abdominal postoperative bleeding successfully treated with low-dose rFVIIa. Methods: We report the case of a 43-year-old man (agreement obtained) who presented for elective colectomy. The patient had type 1 OI associated with left-sided deafness and caracteristic blue sclerae. He had no history of bleeding diathesis or thrombosis. Results: The intra-operative hemorrhage was initially thought to arise from a laceration on the spleen and a splenectomy was performed. The ensuing exploration allowed noticing massive diffuse bleeding. The mechanically ventilated patient was transferred to the ICU. Important blood losses persisted through abdominal drains, the absence of blood clotting was observed. Massive transfusions and DDAVP 20 µg IV were given without improvement. Confronted with continuing massive haemorrhage, rFVIIa (Niastase, Novo Nordisk) 1,2 mg IV (15µg/kg) was given. Within minutes, bleeding decreased drastically and formation of clot was observed. However, bleeding persisted around 200ml/h and tranexamic acid 30mg/kg IV was given followed by a perfusion. Only 2 PRBC were given after the rFVIIa. Total losses were evaluated to 13,5L. The patient was released from the ICU 75 days later, after correction of several non-hemorragic complications. Discussion: The use of DDAVP did not decrease the bleeding as it has been reported in OI in literature(2). The only application of rFVIIa in hemorrhage in OI was successful with 40µg/kg(3). The doses reported in literature vary from 20 to 200µg/kg(4). We opted for a low dose regimen to diminish the risks of thromboembolic events(5). The dose of tranexamic acid used in our case is comparable to those cited in cardiac surgery context. Owing to OI, the risk of thrombosis in our patient probably was lowered because of the collagen anomaly. Of note, our patient never developed DIC although massive blood losses would have normally triggered maximal coagulation. Our observation shows that in massive intraabdominal hemorrhage secondary to surgery in the context of OI recombinant factor VIIa is effective at a lower dosage compared to that generally used in the off-label situations.
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