The aim of this study was to investigate the accuracy of bone mineral density (BMD) determined by quantitative computed tomography (qCT) based on in situ and ex situ scans of cadavers of variable stature. The in uence of surrounding tissue on the quanti cation of CT images of ex situ scanned femora was investigated in air and in water and compared with the in situ scanned femora. The study showed that the surrounding tissue has an impact on the grey value-based representation of the scanned object as well as on the calibration of BMD, in uencing the determination of BMD. Local di erences in BMD of up to 17.5% were observed, which might originate from beam hardening artifacts.
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