Chlorothiazide was synthesized by Novello and Sprague' and found to be a potent, orally effective diuretic and saluretic agent by Beyer, Baer, RUSSO, and Haimbach.2 Ford, Moyer, and Spurr3 have reported on its diuretic and saluretic properties in patients with edema. Because of its pronounced saluretic action a clinical trial of this agent was undertaken in hypertensive patients.The present report covers our experience to date in 105 patients, 90 of whom were hypertensive. In the beginning our major interest was in the attempt to potentiate the action of other antihypertensive drugs. A summary of early results was submitted as an abstract to
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