The development of microfluidic processes requires information-rich detection methods. Here we introduce the concept of remote detection exchange NMR spectroscopy (RD-EXSY), and show that, along with indirect spatial information extracted from time-of-flight data, it provides unique information about the active regions, reaction pathways, and intermediate products in a lab-on-a-chip reactor. Furthermore, we demonstrate that direct spatial resolution can be added to RD-EXSY efficiently by applying the principles of Hadamard spectroscopy.Microfluidics exhibit revolutionary new technological capabilities due to the precise and flexible channel design, efficient heat exchange, high mechanical stability, and economical use of reactants. [1] Microfluidic processes, such as chemical reactions, protein crystallization, cell growth, drug discovery, and health diagnostics, [2] are traditionally monitored by optical, electrochemical, and mass spectrometry methods. [3] Nuclear magnetic resonance (NMR) spectroscopy [4] is one of the most powerful analytical techniques, because it provides versatile spectroscopic, spatial, and dynamic information, and, contrary to optical methods, it allows the noninvasive, tracer-less analysis of opaque materials. The versatile analytical toolbox of NMR spectroscopy can also be exploited in microfluidic applications, if the sensitivity is boosted by using ultrasensitive miniaturized coil designs,[*] Dr.