Statistically significant improvements in arm function have been demonstrated following a programme of home-strengthening hand exercises in RA patients compared with simple stretches or advice alone.

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The RA PREM and the modified PREM provide new valuable validated tools for capturing the patient experience in a range of rheumatic conditions. The RA PREM is currently being used in a UK National Clinical Audit of Rheumatoid and Early Inflammatory Arthritis.

Our interest in structure-metabolism relationships of pharmacologically active l-phenyl-2-aminopropanes has led to in vivo investigations of the fate of the psychotomimetic amine l-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (1). Compound 1 was resolved via its o-nitrotartranilate salts and the absolute configurations were found to be (S)-( + ) and (fi)-(-). Determination of the enantiomeric composition of unmetabolized amine excreted in the urine of rabbits treated with racemic 1 established the R/S ratio to be equal to or greater than 1. With the aid of 1-14C (labeled at the benzylic position) ft has been established that 1 was extensively metabolized by the rabbit and that of several suspected metabolites only l-(2,5-dimethoxy-4-carboxyphenyl)-2-aminopropane was excreted to any great extent.