It has recently been established that the rate of progression of chronic renal failure in man can be slowed by restricting dietary protein. Consequently, the short term and long term effects of a low protein diet on the course of different chronic nephropathies were studied in an attempt to delineate the factors that determine the response to such a diet. When a low protein diet was given for six months renal function improved significantly in nine patients with chronic tubulointerstitial nephritis (p <0 025); the diet had a marginally beneficial effect in 12 patients with chronic glomerulonephritis (p <0 05) and no effect in nine with hypertensive nephrosclerosis. The heterogenous functional response in the patients with chronic glomerulonephritis correlated closely with the effect of the diet on these patients' proteinuria (r=0 76, p <0 01). In a short term study (four weeks) of 12 patients with chronic renal failure changes in renal plasma flow were proportional to dietary protein intake. Renal vascular resistance fell during a high protein diet and increased when dietary protein was restricted. The changes in renal plasma flow during the low protein diet correlated well with the patients' long term functional response to the diet (r-0076, p <0 01).It is concluded that the response to a low protein diet in chronic renal failure is determined, firstly, by the nature of the underlying nephropathy, with maximal benefit being observed in non-glomerular disorders;
Estimation of phytanic acid in human plasma and in a number of foodstuffs is described.Int J Food Sci Nutr Downloaded from informahealthcare.com by Flinders University of South Australia on 02/04/15For personal use only.
Polar stationary No n-pol ar stationaryInt J Food Sci Nutr Downloaded from informahealthcare.com by Flinders University of South Australia on 02/04/15For personal use only.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.