An IgM lambda cold agglutinin reacted preferentially with newborn (i cord) and i adult erythrocytes. The whole serum of patient Vo and the antibody isolated by warm elution reacted moderately with native and neuraminidase-treated red cells but strongly with papainized red cells. Papainization of erythrocytes enhanced markedly the susceptibility of the corresponding antigen not only to antibody binding but also to the action of neuraminidase, indicating that sialic acid is the immunodominant component of the cryptic antigen. The cold agglutinin Vo is the first example of a human monoclonal antibody recognizing a sialic acid-dependent, developmentally regulated antigen fully expressed on newborn erythrocytes.
What do we find at the origin of the work which does most honour to mankind, at the roots of a movement which has been spread across the world for the past hundred years? There is of course one man, Henry Dunant, but there is also a book. A slight volume which was soon to stir the hearts and consciences of Europe from end to end, by its fluent style, its stark reality and its warmhearted appeal. This was A Memory of Solferino.
A l'origine de l'æuvre qui honore le plus l'humanité, à la racine d'un mouvement qui depuis un siècle s'est étendu au monde entier, que voyons-nous? Un homme, bien sûr, Henry Dunant, mais aussi un livre; c'est un mince ouvrage, de 115 pages seulement, dont l'éloquence, le pouvoir de choc et l'appel généreux sur lequel il s'achève, émurent bientôt les cœurs et les consciences d'un bout à l'autre de l'Europe, Un Souvenir de Solférino.
An IgMλ cold agglutinin reacted preferentially with newborn (i cord) and i adult
erythrocytes. The whole serum of patient Vo and the antibody isolated by warm elution
reacted moderately with native and neuraminidase-treated red cells but strongly with
papainized red cells. Papainization of erythrocytes enhanced markedly the susceptibility of
the corresponding antigen not only to antibody binding but also to the action of neuraminidase,
indicating that sialic acid is the immunodominant component of the cryptic antigen.
The cold agglutinin Vo is the first example of a human monoclonal antibody recognizing a
sialic acid-dependent, developmentally regulated antigen fully expressed on newborn erythrocytes.
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