There was a lack of consensus on the management of breast cancer among clinicians in 1990. More patients should be included in clinical trials.

Anne-Marie Chouillet-Roche : Father Castel's ocular harpsichord. Father Castel (1688-1757) was most famous as the inventor of a mathematical machine, the ocular harpsichord, and as an opponent of Newtonianism. He believed that there were 3 prime colours and no fundamental difference between sound and light, and he attempted to find the bijection between colours and notes of the chromatic scale and to calculate the number of degrees of shading. The author studies his machine through texts by Castel and his contemporaries, and gives a bibliography of his main works as well as of the chief studies of his harpsichord.

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