Branching out: Novel branched ubiquitin isopeptide activity‐based probes (UIPPs) were engineered to profile ubiquitin (Ub) linkage specificity of deubiquitinating enzymes (DUBs) in cell extracts. Using chemical proteomics, a preference towards K48‐linked Ub was shown for USP5, USP7, UCH L‐3, and UCH L‐5, whereas USP19 and USP38 preferred K63‐linked Ub.
Sublethal Lm infection deregulates hepatic drug metabolizing pathways. This finding indicates the need to monitor drug administration along Lm infections, especially in all patients needing constant medication.
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