Overexpression of epidermal growth factor receptor (EGFR) is a common phenomenon observed in most cancers. Clinical treatment of such cancer involves the use of chemotherapeutic agents such as ge ? tinib and erlotinib which are inhibitors of tyrosine kinase (TK). These small molecules bind to the ATP-binding sites of the TK domain of EGFR.Our in silico analysis suggests that the TK domains of Drosophila and human EGFR are highly conserved. We therefore employed the Drosophila system to validate the in silico observations made with two important anticancer drugs.Since a large number of mutant flies are available,it was possible to investigate the various components of the EGFR/Ras/Raf/MAPK pathways and the phosphorylation status of diphosphorylated extracellular signal-regulated kinase (dp-ERK1/2). These studies confirm the binding of the anilinoquinazolines to the Drosophila EGFR protein and modulation of its activity. Thus,Drosophila appears to be a robust and simple model system for screening newer anticancer drugs that act as TK inhibitors (TKIs).
The main objective of this study is to use coconut husk to produce mortar for ferrocement. Mortar mix proportions are selected per ACI codes’ recommendation and the WRD Handbook. Four types of mortars: Cement and River Sand mortar (CSM), Cement, River Sand and Steel fibre mortar (CSSFM), Cement and Coconut Husk mortar (CCHM), and Cement, River Sand (60%), Coconut Husk (40%), and Steel fibre mortar (CSCHSFM) are used for this study Microstructural studies like SEM, EDX, XRD, and FTIR analysis on cement mortar constituents and mortar mixes are studied and reported. At 3, 7, and 28 days tests of hardened mortar, such as compressive, split tensile, flexural strength, and impact strength resistance, were studied. Test results revealed that the coconut husk is innovative and sustainable and could be an alternative fine aggregate that can be utilized in place of river sand, which in turn can be used for mortar production. Since it has a lesser density which proves to be an advantage for developing lightweight mortar, it can be used for ferrocement applications.
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