The mixing of confined liquids is a central yet challenging operation in miniaturized devices. Microfluidic mixing is usually achieved with passive mixers that are robust but poorly flexible, or active mixers that offer dynamic control but mainly rely on electrical or mechanical transducers, which increase the fragility, cost, and complexity of the device. Here, we describe the first remote and reversible control of microfluidic mixing triggered by a light illumination simply provided by an external LED illumination device. The approach is based on the light-induced generation of water microdroplets acting as reversible stirrers of two continuous oil phase flows containing samples to be mixed. We demonstrate many cycles of reversible photoinduced transitions between a nonmixing behavior and full homogenization of the two oil phases. The method is cheap, portable, and adaptable to many device configurations, thus constituting an essential brick for the generation of future all-optofluidic chip.

Microdroplet-based organic syntheses have been developed as a valuable alternative to traditional bulk-based methods. However, unlike their water counterparts, organic microdroplets can prove challenging to manipulate. Here, we describe the first optical manipulation of discrete, nanoliter- to microliter-sized apolar droplets floating on a liquid surface to induce on-demand droplet fusion for organic synthesis. We demonstrate droplet transport on centimeter-scale distances at speeds of 0.1 to 1 mm·s(-1) with well-programmable, sequential or parallel, fusion events. Because our strategy is compatible with most usual hydrocarbon solvents, such droplets can be used as microcompartments for reagents. Organic reactions readily occur upon droplet fusion, as demonstrated with an ene reaction. With an LED as the sole power source, and without any fabrication step, optical setup, pump or electrode implementation, our method provides a robust and versatile way to place digital organic chemistry under optical control.