Palladium(II) and platinum(II) chloro complexes of novel water‐soluble cage‐like phosphane CAP (1,4,7‐triaza‐9‐phosphatricyclo[5.3.2.14,9]tridecane) have been synthesized and characterized in comparison with their counterparts bearing well known PTA (1,3,5‐triaza‐7‐phosphaadamantane) ligand. A peculiar structural feature of studied cis‐[MCl2L2] complexes is the occurrence of interligand C−Hσ+⋅⋅⋅σ+H−C interactions (hydrogen‐hydrogen bonds) between the phosphane cages: the first case encountered so far among metal‐phosphane complexes. Due to substantial stabilizing contribution to the net molecular energy of the complexes (∼ 20 kcal mol−1), hydrogen‐hydrogen bonding is sufficient to maintain sterically overcrowded cis conformations of the complexes. The interplay between protonation stage of the ligands and their conformations can be a reason of significant differences in in‐vitro cytotoxicity between CAP complexes and their PTA‐bearing counterparts.
We analyzed previously generated stable monocyte-derived cell line carrying mutation JAK2 V617F. Evaluation of the expression of pro- and antifibrotic factors revealed changes in the production of MMPs and their inhibitors, growth factors, galectin-3, and pentraxin 3 in cells carrying mutation JAK2 in comparison with control non-modified cells.
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