Fig. 1. Rapid clinical response of hidradenitis suppurativa (HS) to secukinumab treatment. Clinical images of the genital and gluteal region (A) before and (B) after 8 weeks of treatment with the interleukin-17A antibody secukinumab, demonstrating rapid reduction in inflammatory nodules and signs of cutaneous inflammation.
Cloverlea] Skull Syndrome Abstract.A case report is presented describing an infant with systemic skeletal malformation including a "cloverleaf skull" (Kleeblattschgdel) cleft formation of the facial bones, mMformation of tile brain, hydrocephalus, and symmetrical notching of hands and feet. This entity has been described as "clover leaf skull syndrome" by Holtermfiller and Wiedemann. The etiology of the syndrome is discussed with special reference to lower abdominal X-ray examinations of the mother in early pregnancy as a possible cause of the disorder. The malformations result most likely from a disturbance in the development of the primitive segments involving mainly cranial somites and extremity buds.
Key-Words:Clover Leaf Skull --Cleft Formation of the Facial Bones --Malformation of the Brain --Other Malformations X-ray Examinations of the Mother in Early Pregnancy.14"
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