At the moment, the problem of preterm birth is one of the most urgent in the modern world. Preterm birth is of the greatest interest in obstetrics, as they can lead to various conditions that interfere with the further development and vital activity of the baby, which can lead to various disorders in the babys body systems, and in the worst case, can also lead to its death. Nowadays, there is no complete understanding of the mechanisms of development of preterm labor. The pathogenesis and pathophysiology of preterm birth are extremely complex, however, of course, many factors affect the development of this process, including the state of the microflora of the female genital tract. This article provides a review of current literature on the effects of bacterial vaginosis and significant infectious microorganisms (Prevotella sp., Mobiluncus sp., Gardnerella vaginalis, Mycoplasma hominis, etc.) on the development of preterm labor. This work presents a review of the current literature on the available data on the effect of various microorganisms of the female genital tract, as well as the significant cytokines, defensins, prostaglandins, and other biologically active substances secreted by them that are most likely involved in the process of preterm delivery. A probable mechanism for the development of preterm labor is presented under the influence of changes in the vaginal microflora and the predominance of pathogenic and conditionally pathogenic flora with the participation of matrix metalloproteinases, phospholipases and ligands of Toll-like receptors.
Uterine myoma is the most common benign tumor among women which affects mainly those of reproductive age. Moreover, the frequency of emergence of this pathology in population is growing while the age of patients is steadily decreasing. Despite the enormous prevalence of this disease, its pathogenesis has not been studied properly. This article is concerned with an analysis of publications devoted to the study of the mechanisms of growth and development of uterine fibroids, it provides some data on the role of various factors in its extension. The article concerns the most popular concepts of the pathogenesis of this disease according to which the illness may be caused by increased levels of sex hormones (estrogens and progestins), enhanced expression of their receptors, impaired apoptosis, the effect of growth factors (e. g. epidermal growth factor, heparin-binding epidermal growth factor, acid and basic fibroblast growth factors, vascular endothelial growth factor, insulin-like growth factor, platelet-derived growth factor, transforming growth factor-β, activin, myostatin), abnormal deposition extracellular matrix, genetic (chromosomal aberration and various MED12 gene defect) and epigenetic mechanisms (such as action microRNA), circulatory disorders and impairment of cell differentiation from a population of accessory stem cells. However, it is noted that the pathogenesis of this pathology requires further detailed study, as the understanding of the processes leading to its development could greatly contribute to the improvement of the tactics of treatment and possibly allow to elaborate some preventive measures to avert the development of fibroids.
This article is devoted to the assessment of the role of ALK5 in the profile of early reproductive losses in the use of assisted reproductive technologies, in particular, by using immunohistochemical study in the group of patients with early spontaneous abortion after the procedure of embryo transfer, a lower level of ALK5 expression in the decidual tissue was revealed (in comparison with control), which may be related to the occurrence of early reproductive losses caused by the imbalance in Th1 / Th2 and its effect on the increase in the concentration of natural killer cells.
Myoma periodically leads to infertility by causing impaired blood flow, aseptic inflammation in the endometrium, increased uterine contractility, impaired sperm migration with cerviсal myoma nodes and obstruction of the proximal fallopian tubes. Objective — The estimation of the quantity and quality of oocytes and embryos in the IVF (in vitro fertilization) protocols in women with uterine fibroids with and without surgical treatment. Material and Methods — The retrospective study included 37 IVF cycles from 37 patients that had infertility combined with myoma. The Group 1 patients were subjected to the IVF procedure without previous treatment of the myoma, while the Group 2 patients were subjected to IVF after myomectomy. Results — The total quantity of oocytes and the percentage of mature (MII) oocytes obtained during the ovarian puncture of the patients in the compared groups were slightly higher in the group without surgical treatment (p>0.05). Any significant differences in the frequency of formation of high-quality embryos (р=0.43) and good-quality embryos (р=0.22) between the groups were not obtained. The number of embryos suitable for embryo transfer to the uterine cavity and/or cryopreservation in the women with myomectomy was 9% higher than the one in the group without surgical treatment. Conclusion — Surgical treatment of uterine fibroids does not significantly affect the quantity and quality of oocytes and embryos obtained in the IVF procedure.
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