Volcanic ash (b2 mm) erupted from the Aeolian Islands is reported distally as layers in sedimentary archives from across the central Mediterranean region. Here we present volcanic glass geochemistry of proximal tephra deposits from explosive eruptions on the islands of Vulcano, Lipari, Salina and Stromboli spanning approximately the last 50 ka using grain-specific EMPA and LA-ICP-MS. This comprehensive database of volcanic glass compo- sitions (N1000 analyses) provides a basis for proximal-distal and distal-distal tephra correlations. Tephra de- posits from the different Aeolian Islands are geochemically diverse; with some individual eruptions showing diagnostic geochemical heterogeneity recognised both stratigraphically and/or spatially. Major element glass analyses reveal that Vulcano (0–21 ka) and Stromboli (4–13 ka) have erupted potassic (shoshonitic and K-series) tephra with broadly overlapping compositions, but data presented here demonstrates that their eruptive prod- ucts can be distinguished using either TiO2 contents or their HFSE/Th ratios. Whilst individual volcanic sources often produce successive tephra deposits with near identical major and minor element compositions through time (i.e., Lipari, Vulcano), trace element glass data can help to decipher successive eruptions. Changes in LREE and Th concentrations of volcanic glasses erupted spanning approximately the last 50 ka greatly enhance the po- tential to discriminate successive eruptive units on Lipari. The new proximal glass database has been used to ver- ify new (Ionian Sea; core M25/4-12) and existing distal occurrences of Aeolian Island derived tephra enabling the reassessments of past ash dispersals. Finally, proximal and distal data have been used to establish an integrated proximal-distal eruptive event stratigraphy for the Aeolian Islands
HighlightsThe manuscript details the rationale, design and protocol for PARADIGM-2.PARADIGM-2 comprises two parallel phase I, dose escalation studies of the PARP inhibitor olaparib in combination with radiotherapy (for MGMT unmethylated patients) and radiotherapy-temozolomide (for MGMT methylated patients) in newly diagnosed glioblastoma.This is a novel approach to phase I dose escalation trial design that maximises the potential for patients with glioblastoma to benefit from the addition of the radio- and chemosensitizing drug olaparib.
Background Patient‐reported outcome measures (PROMs) are important tools to inform patients, clinicians and policy‐makers about clinical need and the effectiveness of any given treatment. Consistent PROM use can promote early symptom detection, help identify unexpected treatment responses and improve therapeutic engagement. Very few studies have examined associations between patient characteristics and PROM data collection. Methods We used the electronic mental health records for 28,382 children and young people (aged 4–17 years) accessing Child and Adolescent Mental Health Services (CAMHS) across four South London boroughs between the 1st of January 2008 to the 1st of October 2017. We examined the completion rates of the caregiver Strengths and Difficulties Questionnaire (SDQ), a ubiquitous PROM for CAMHS at baseline and 6‐month follow‐up. Results and Conclusions SDQs were present for approximately 40% (n = 11,212) of the sample at baseline, and from these, only 8% (n = 928) had a follow‐up SDQ. Patterns of unequal PROM collection by sociodemographic factors were identified: males were more likely (aOR 1.07, 95% CI 1.01–1.13), whilst older age (aOR 0.87, 95% CI 0.87–0.88), Black (aOR 0.79 95% CI 0.74–0.84) and Asian ethnicity (aOR 0.75 95% CI 0.66–0.86) relative to White ethnicity, and residence within the most deprived neighbourhood (aOR 0.87 95% CI 0.80–0.94) were less likely to have a record of baseline SDQ. Similar results were found in the sub‐group (n = 11,212) with follow‐up SDQ collection. Our findings indicate systematic differences in the currently available PROMS data and highlights which groups require increased focus if we are to gain equitable PROM collection. We need to ensure representative PROM collection for all individuals accessing treatment, regardless of ethnic or socioeconomic background; biased data have adverse ramifications for policy and service level decision‐making.
[1] To better understand the mechanics and seismic potential of nonplanar fault surfaces, we present results from a suite of numerical models of faults with sinusoidal corrugations in the downdip direction. Systematic variations in corrugation wavelength, amplitude, and loading angle are introduced to determine the effects on slip behavior and seismic moment release. We find that corrugated faults, in general, slip less than planar faults. Changes in slip behavior are nearly scale-independent and are dominantly controlled by the amplitude/wavelength of corrugations. Model results suggest that obliquely loaded corrugated faults accumulate less strike slip than a planar fault with the same tip line dimensions and average orientation. This result implies that slip direction is not a reliable indicator of regional stress direction and may at least partially explain repeated, nearly pure dip-slip coseismic events at oblique plate boundaries. Though the scalar seismic moment release is always less for corrugated fault surfaces due to a greater reduction in slip compared to increased surface area, for geologically reasonable corrugation geometries, changes in total scalar moment release are not significantly different than planar faults. Techniques that utilize highly simplified fault geometries may therefore accurately reproduce scalar moment release but will nonetheless incorrectly predict coseismic slip magnitudes and distributions, as well as regional stress orientations.Citation: Marshall, S. T., and A. C. Morris (2012), Mechanics, slip behavior, and seismic potential of corrugated dip-slip faults,
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