Hypertension is considered a relevant risk factor for cardiovascular mortality and morbidity.Over the years it has been demonstrated that adaptive and innate immune responses in experimental models are modulated by aldosterone. This study aimed at demonstrating that secondary hypertension is characterised by the Th17/Treg imbalance. Moreover, it was designed to establish a positive correlation between elevated systolic blood pressure and increased numbers of CD4+IL-17+ and CD4+CD25+FOXP3+ T-cells in primary hyperaldosteronism.
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