What is new?Fibromyalgia (FM) patients are heterogenous in metabolic status. Contrary to the previously published data our study shows that only a subgroup of FM patients is characterized by insulin resistance. FM patients who are responsive to SNRI (serotonin and noradrenalin reuptake inhibitors) treatment have similar levels of fasting glucose, insulin, insulin resistance, BMI compared to healthy controls. However, FM patients who are not responsive to treatment with SNRI are characterized by higher fasting glucose, fasting insulin, insulin resistance, BMI compared to healthy controls and to FM patients responsive to SNRI. FM patients who are not responsive to treatment with SNRI present higher prevalence of depression, anxiety and personality disorders than those responsive to SNRI. Insulin resistance, depression, anxiety and personality disorders are predictors of the lack of response to treatment with SNRI in fibromyalgia.
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