To evaluate the hypothesis that endocrine profiles change with aging independently of specific disease states, we examined the age trends of 17 major sex hormones, metabolites, and related serum proteins in 2 large groups of adult males drawn from the Massachusetts Male Aging Study, a population-based cross-sectional survey of men aged 39-70 yr conducted in 1986-89. Group 1 consisted of 415 men who were free of obesity, alcoholism, all prescription medication, prostate problems, and chronic illness (cancer, coronary heart disease, hypertension, diabetes, and ulcer). Group 2 consisted of 1294 men who reported 1 or more of the above conditions. Each age trend was satisfactorily described by a constant percent change per yr between ages 39-70 yr. Free testosterone declined by 1.2%/yr, and albumin-bound testosterone by 1.0%/yr. Sex hormone-binding globulin (SHBG), the major serum carrier of testosterone, increased by 1.2%/yr, with the net effect that total serum testosterone declined more slowly (0.4%/yr) than the free or albumin-bound pools alone. Among the major androgens and metabolites, androstane-3 alpha,17 beta-diol (androstanediol; 0.8%/yr) and androstanediol glucuronide (0.6%/yr) declined less rapidly than free testosterone, while 5 alpha-dihydrotestosterone remained essentially constant between ages 39-70 yr. Androstenedione declined at 1.3%/yr, a rate comparable to that of free testosterone, while the adrenal androgen dehydroepiandrosterone (3.1%/yr) and its sulfate (2.2%/yr) declined 2-3 times more rapidly. The levels of testosterone, SHBG, and several androgen metabolites followed a parallel course in groups 1 and 2, remaining consistently 10-15% lower in group 2 across the age range of the study. Subgroup analyses suggested that obese subjects might be responsible for much of the group difference in androgen level. Serum concentrations of estrogens and cortisol did not change significantly with age or differ between groups. Of the pituitary gonadotropins, FSH increased at 1.9%/yr, LH increased at 1.3%/yr, and PRL declined at 0.4%/yr, with no significant difference between groups 1 and 2.(ABSTRACT TRUNCATED AT 400 WORDS)

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This paper examines the relation of two personality characteristics (dominance and anger) to hormones in normally aging men. The relation of the Jackson Personality Research Form E Dominance subscale and the Spielberger Anger Expression scale to serum levels of 17 endocrine variables, including testosterone (T) and dihydrotestosterone (DHT), cortisol, and prolactin, was examined in 1709 men aged 39 to 70 years randomly sampled from the Boston Metropolitan Statistical Area. Canonical correlation analysis resulted in the identification of a personality profile characterized as dominant with some aggressive behavior that tends to correlate with a hormonal pattern labeled the "availability of androgens." These results partially support previous findings in animals, adolescents, and criminal populations that "aggressive dominance" is related to testosterone.

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Objectives This study aimed to explore how first‐time mothers in the UK experienced new parenthood during the coronavirus (COVID‐19) pandemic. Design This study used a cross‐sectional exploratory, qualitative interview design. Methods Semi‐structured interviews were conducted with ten first‐time mothers who had given birth since COVID‐19 was declared as a pandemic. Verbatim transcripts were analysed using reflexive thematic analysis. Result Experiences of new, first‐time mothers during the COVID‐19 pandemic were organized around two themes. First, new mothers felt an overwhelming sense of responsibility for their baby which was heightened by the pandemic. The challenge of meeting this responsibility was heightened in the context of societal expectations to do the ‘right’ thing and uncertainty and distrust around official guidance about COVID‐19. Secondly, the expected transition into motherhood was altered by the pandemic. Disruption to the birthing experience, an inability to connect with close friends and family, and limited healthcare support was perceived to be detrimental. However, altered social expectations and the increased presence of the partner were perceived as positives. Conclusion Many of the common challenges experienced by new, first‐time mothers have been amplified by the COVID‐19 pandemic. Public policy and scientific research must target this group in order to protect this population from the negative impact of the remaining COVID‐19 pandemic and any future pandemics.