The pharmacokinetics of ciprofloxacin, administered orally as a 250-mg tablet were compared in 10 young (age 20–30 years) and 10 elderly (age 60–73 years) healthy volunteers. The time to peak serum concentrations was about 80 min in both age groups, although the maximum concentration attained was significantly greater in the old (1.7mg/l) than the young (1.2 mg/l). Area under the plasma concentration-time curve, corrected for body weight, was on average 48% greater in the elderly, but the mean terminal elimination half-life was not significantly different, averaging 4.3 h in the old and 3.7 h in the young. Overall 24-hour urinary recovery in both age groups was comparable. The differences may be explained by a reduced volume of distribution of ciprofloxacin in old age and do not suggest a general need for significant dose alteration in the elderly.

Background/Objectives: The genus Acinetobacter demonstrates resistance to antibiotics and has been shown to spread in the hospital environment causing epidemic outbreaks among hospitalized patients. The objectives of the present study was to investigate the antibiotic resistance, biofilm formation, and clonality among Acinetobacter baumannii strains. Materials and Methods: The study involved 6 (I Outbreak) and 3 (II Outbreak) A. baumannii strains isolated from patients hospitalized in vascular surgery unit. Results: All tested A. baumannii strains were extensively drug resistant (XDR) and all the isolates were carbapenem-resistant and among them, all carried the blaOXA-51 gene, the blaOXA-24 gene, as well as the blaOXA-23 gene. All of the investigated strains had the ability to form a biofilm, but all of them produced less biofilm than the reference strain. Multi-locus sequence typing (MLST) showed that all strains belonged to the ST2 clone. Pulsed-field gel electrophoresis (PFGE) divided the tested outbreak strains into two clones (A and B). Conclusion: This study shows a nosocomial spread of XDR A. baumannii ST2 having the blaOXA-51 gene, the blaOXA-24 gene, as well as the blaOXA-23 gene, low biofilm formers, that was prevalent in the vascular surgery unit. To identify the current situation of vascular surgery departments targeted epidemiological investigation was needed. Effective implementation of infection control prevented the spread of the epidemic outbreaks.

Der Beitrag befasst sich mit dem weniger beachteten poetischen Konzept Ernst Jandls, das in der zweiten Hälfte der 70er Jahre entstanden ist. Bemerkenswert erscheinen die Gedichte insofern, als sie die Lyrik des Autors, der als Sprachspieler und Sprachclown bekannt wurde, in einem anderen Licht darstellen. In dieser Reihe wendet sich Jandl der düsteren Seite der menschlichen Existenz zu und drückt diese in Form der „heruntergekommenen Sprache“ aus. Der vorliegende Aufsatz stellt eine Probe dar, den Spuren des lyrischen Ich nachzugehen, das zwischen Auflösung und Affirmation schwankt und sich in kurzen affirmativen Momenten als Ganzes zu behaupten versucht.

„Terra grammatica: Ideen – Methoden – Modelle“. Obrzycko, 27.-29.9.2006 „Verbalisierung und Visualisierung der Erinnerung. Literatur und Medien in Österreich“. Polnisch-österreichisches Germanistentreffen,Łódź, 27.9.-30.9.2006 „Die Architektur der Weiblichkeit. Die Identitätskonstruktionen in der zeitgenössischen Literatur der österreichischen Autorinnen.“Internationale Konferenz in Poznań, 19.-20.4.2007 „Germanistische Wahrnehmungen der Multimedialität, Multilingualität und Multikulturalität“. Internationale wissenschaftlicheTagung des Verbandes Polnischer Germanisten. Opole, 11.-13.5.2007

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