Background: Protein phosphatases exist as multisubunit complexes. Results: Two protein kinases in endogenous brain protein phosphatase 1 I were found to regulate its activation in opposing directions through inhibitor 2 phosphorylation. Conclusion: These kinases support a signaling cascade that regulates protein phosphatase 1 I activation in global cerebral ischemia. Significance: Understanding the signaling pathways regulating the activity of protein phosphatases is critical to elucidating their physiological and pathological roles.
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