Introduction: Quality of evidence regarding telemedicine in adults with peripheral arterial disease has not been systematically appraised. Objectives: To explore benefits and harms from mobile information communication technology devices and applications in peripheral arterial disease. Methods: Systematic rapid evidence review and appraisal with the grading of recommendations assessment, development, and evaluation working group approach. Results: Sixteen randomized controlled clinical trials (RCT) examined various self-monitoring devices, telemedicine platforms, and individualized telephone counseling. Low-quality evidence suggested that the odds of treatment failure (pooled Peto odds ratio 0.8; 95% CI, 0.4-1.7; 5 RCTs), adverse effects (pooled Peto odds ratio 0.9; 95% CI, 0.5-1.5; 2 RCTs), and physical performance (standardized mean difference in 6-minute walking test 0.2; 95% CI, -0.3-0.7; 4 RCTs) did not differ between mobile interventions and usual care. Single RCTs suggested large but inconsistent improvement in the quality of life: EuroQol5D standardized mean difference = 5.0 (95% CI, 4.4-5.7; 1 RCT) after telehealth program for promoting patient self-management and standardized mean difference = 1.4 (95% CI, 0.4-2.3; 1 RCT) after structured rehabilitation with mobile self-monitoring. Inconsistent reporting of patientcentered outcomes and small sample sizes hampered the quality of evidence. Conclusions: Improved quality of life after specific mobile applications should be confirmed in powered RCTs and large postmarketing studies.
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