No abstract

GSK2618960 was well tolerated and blocked IL-7 receptor signalling upon full target engagement. Although there was no discernible impact on peripheral T cell subsets in healthy subjects, GSK2618960 may effectively modulate the autoinflammatory activity of pathogenic T cells in diseased tissue. A relatively short half-life is likely the result of target-mediated rather than ADA-mediated clearance.

No abstract

The postnatal development of the spiral ganglion in the albino rat was studied using light and electron microscopy. The morphological characteristics distinguishing type 1 from type 2 spiral ganglion cells were defined, and the critical period for distinguishing the two types of neurons was identified. At birth, the spiral ganglion consists of a homogeneous population of small, densely packed, spherical cells that have large cytoplasmic-to-nuclear ratios. During the first postnatal week, the cells mature slowly. At this period the myelin sheath around the cell bodies generally consists of only a few layers of loose myelin. Long glial fingers extend around the cell processes and soma, particularly the filopodial extensions of the somatic membrane. Type 2 spiral ganglion cells can be distinguished at postnatal day 8. Viewed with the phase-contrast microscope these cells are smaller and have more darkly staining nuclei and more lightly staining cytoplasm than the type 1 cells. The most characteristic ultrastructural features of the type 2 neurons are the densely packed neurofilaments in the cytoplasm and lack of compact myelin around the cell soma. By day 14, spiral ganglion cells are morphologically mature, although the myelin sheath continues to thicken. The results are discussed in relation to the electrophysiological development of the auditory system and the morphological maturation of the organ of Corti.