Handwriting research lies mostly within discipline-specific boundaries, hindering knowledge transfer across disciplines into academic skills instruction in schools. This paper attempts to review the literature on handwriting across the occupational therapy and education disciplines to propose an interdisciplinary conceptual framework to guide research and intervention on handwriting in the Malay language. This cross-disciplinary review revealed four major factors that may influence Malay language handwriting: i) neuromotor development; ii) ergonomic; iii) orthographic and iv) cognitive factors. The sub-factors under these four major factors also are identified. Many of the neuromotor development and ergonomic factors are derived from the occupational therapy discipline, while the education discipline provides most of the information on orthographic and cognitive factors. As orthography influences handwriting, it is necessary to revisit handwriting from the perspective of languages other than English. In conclusion, an interdisciplinary framework of handwriting synthesised from this crossdisciplinary review will stimulate more coordinated and coherent research on handwriting. The Malay language serves as a future case study for research into orthographies in handwriting.