Lipophilic drugs comprise of majority of the active pharmaceutical ingredients which shows the lower oral bioavailability. Many methods have been used to enhance the bioavailability, especially the lipid-based formulations have gained a lot of attention of the researchers, one among the lipid-based formulation approach is the self-emulsifying drug delivery system (SEDDS). SEDDS basically is an isotropic mixture of oils, surfactants and co-surfactants or co-solvents, which after reaching the gastro intestinal tract (GIT) emulsifies itself to emulsion upon mild agitation in the stomach. Solid self-emulsifying drug delivery system (S-SEDDS) is one of advancements in the self-emulsifying systems, which uses the adsorbents where the liquid self-emulsifying system adsorbs and converts itself in to solid, which overcomes the disadvantages of the liquid SEDDS. Various S-SEDDS have been developed in recent years and few of them are, tablets, pellets, microbeads, suppositories, nanoparticles, patches, microspheres etc, without any compromise in the drug release kinetics. These formulations are the cost-effective means of enhancing the bioavailability of the lipophilic drugs.
Tobramycin is a potent antimicrobial aminoglycoside that can be used to treat ocular infections. Its solubility and bioavailability are limited, so its solid dispersion was prepared using PVP-K30, HPMC and Beta cyclodextrin by solvent evaporation technique. This solid dispersion was formulated as an eye drop using sodium chloride, EDTA and benzalkonium chloride. Totally 9 formulations were prepared. The in-vitro dissolution profile of optimised formulation (F6) showed 85.1% drug release at the end of 2nd hour. The optimized formula was evaluated which showed no microbial growth, and drug content uniformity was 80.12% to 85%. The optimized formulation was evaluated for clarity, pH, isotonicity, microbial growth, stability and in vitro diffusion studies and all these showed acceptable results.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.