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Abstract-While research on cross-layer network optimization has been progressing, useful implementations have been lagging because the current Internet architecture does not accommodate cross-layering gracefully. As part of our FIND project, we propose a software architecture for the future Internet that is designed to accommodate such interactions. We present a conceptual overview as well as high level software design and an early prototype implementation, and point out the strengths of our architecture.

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QoS-aware video streaming is demonstrated on an optical network using a serviceoriented architecture and a NetFPGA-based optical control plane. Dynamic optical power fluctuations are either compensated or the lightpath is rerouted to ensure the QoS.

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Acute kidney injury (AKI) is a complex clinical syndrome with a poor short-term prognosis, which increases the risk of the development of chronic kidney diseases (CKD) and end-stage kidney disease (ESKD). However, the underlying mechanism of AKI remains to be fully elucidated, and effective prevention and therapeutic strategies are still lacking. Given the enormous energy requirements for filtration and absorption, the kidneys are rich in mitochondria, which are unsurprisingly involved in the onset or progression of AKI. Accumulating evidence has recently documented that Sirtuin 3 (SIRT3), one of the most prominent deacetylases highly expressed in the mitochondria, exerts a protective effect on AKI. SIRT3 protects against AKI by regulating energy metabolism, inhibiting oxidative stress, suppressing inflammation, ameliorating apoptosis, inhibiting early-stage fibrosis, and maintaining mitochondrial homeostasis. Besides, a number of SIRT3 activators have exhibited renoprotective properties both in animal models and in vitro experiments, but have not yet been applied to clinical practice, indicating a promising therapeutic approach. In this review, we unravel and summarize the recent advances in SIRT3 research and the potential therapy of SIRT3 activators in AKI.