Disseminated histoplasmosis is caused by the dimorphic fungus Histoplasma capsulatum. This fungal infection is commonly seen in immunocompromised patients, especially in AIDS patients, children and elderly population. Here we present a case report of a 24-year-old male who was admitted with generalised fatigue and generalised lymphadenopathy. He was found to be retropositive on evaluation and FNAC of the node surprisingly revealed Histoplasmosis. Presence of these organisms were also seen on the peripheral smear which could be picked up only on reviewing the smear again. With this case report we wish to emphasize the need for careful and diligent search of these organisms in the peripheral smear.
Background: Non small cell carcinomas of lung, notably adenocarcinoma is associated with genetic mutations in EGFR
(chromosome 7) , ALK (chromosome 2), ROS1(chromosome 6) . The patients harbouring these mutations are greatly
benefited from tyrosine kinase inhibitor targeted chemotherapy. The prevalence of these mutations in central kerala has
not been studied and documented.
Aim: This study aims to analyse the frequency of different mutations in lung adenocarcinomas presenting to a oncology
centre in kerala.
Study Design: Descriptive study.
Materials And Methods: The study spanned over a period of two years from 2019-2021. A total of 169 consecutive lung
adenocarcinomas were studied.
PCR for EGFR was done in 89 cases and were tested for the common mutations. ALK1 IHC using ALK-D5F3 clone and ROS
with ROS-D4D6 clones were done in 40 cases.
Results: EGFR mutation was present in 15 cases (17.44%). The most common age range was 40-60yrs. Two most
common patterns were solid and acinar. ALK and ROS 1 mutation was found in 3 cases (7.5%) and 2 cases ( 5%)
respectively. 4 cases (16.66%) of EGFR mutant lung adenocarcinoma patients had metastasis.
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