We report herein a general catalytic method for Csp(2)-Csp(3) bond formation through C-F activation. The process uses an inexpensive nickel complex with either diorganozinc or alkylzinc halide reagents, including those with β-hydrogen atoms. A variety of fluorine substitution patterns and functional groups can be readily incorporated. Sequential reactions involving different precatalysts and coupling partners permit the synthesis of densely functionalized fluorinated building blocks.
A new route to generate alkyl substituted aryl fluorides, such as (III), (V), (VIII) and (XI) through Ni‐catalyzed Negishi cross‐coupling reactions is described.
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