Insomnia means difficulty in falling asleep and/or stays asleep. Insomnia commonly leads to daytime sleepiness, lethargy, and a general feeling of being unwell. The most common treatment of insomnia includes GABAA receptor positive allosteric modulators or Melatonin agonists. Our study aimed to evaluate the efficacy of Magnesium- melatonin-vitamin B complex supplement in the treatment of insomnia. The study included 60 patients diagnosed with insomnia. The patients were randomly divided into study group (N = 30), and control group (N = 30), and study group was treated with Magnesium-melatonin-vitamin B complex (one dose contains 175 mg liposomal magnesium oxide, 10 mg Vit B6, 16 μg vit B12, melatonin 1 mg, Extrafolate-S 600 μg) once a day 1 hour before sleep, during the 3 months. The severity of insomnia symptoms was measured by self-reported Athens insomnia scale (AIS), with a cut-off score by Soldatos (AIS score ≥ 6). Mean AIS score at zero points was 14.93 ± 3.778 in the study group and 14.37 ± 4.081 in the control group (p = 0.476), indicating the compatibility of the groups, and both scores correspond to mild to moderate insomnia. Mean AIS score after 3 months of the Magnesium- melatonin- vitamin B complex supplementation was 10.50 ± 4.21 corresponding to mild insomnia, while median AIS score in the control group was 15.13 ± 3.76 which is referred to moderate insomnia, and difference among groups was significant (p = 0.000). Our founding’s indicating that 3 months of the Magnesium- melatonin-vitamin B complex supplementation has a beneficial effect in the treatment of insomnia regardless of cause.
At every place in the article word Fluimucil is replaced by NAC (N-acetil-cysteine) as follows: 1. Article titles (English and Serbian version) from the Content, general article title (page 33) and article headers at the pages 33-41. 2. INTRODUCTION - Last sentence in the Introduction section (page 34). 3. MATERIAL AND METHOD - Second sentence in the first paragraph (page 34); Second column, third paragraph (page 34). 4. RESULTS - First column, second paragraph at the page 36; Figure 2 title (page 37); first column, first paragraph (page 37); subtitle (page 37); text second column, second paragraph (page 37); Table 3 header (page 38); first column first paragraph text below the table 3 (page 38); text below the subtitle: second column, second paragraph (page 38); text below Figure 3 (legend, page 38); Table 4 header (page 39). 5. CONCLUSION - page 40. The authors would like to apologise for any inconvenience caused.
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