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Non-Hodgkin's lymphoma (NHL) belongs to a group of lymphoid neoplasms that is diverse in manner of presentation, response to therapy and prognosis. Usually oral manifestations of NHL are secondary to a more widespread involvement throughout th e bo dy. Tho ugh primary in traoral lesio ns in NHL are uncommon, it is important to be aware of them, since intraoral manifestations are the presenting symptoms in these patients.2 A 58-year-old man presented to our Department with swelling in the vestibule of mouth. CT scan revealed a mass on upper gingival without any bony involvement. Incisional biopsy of the lesion showed diffuse large B cell lymphoma. The patient was treated successfully with chemotherapy. One year after complete remission, patient developed recurrence of primary tumor for which patient was again given chemotherapy treatment but had no significant benefit and succumb to the disease. How to cite this article Kaul A, Kalsotra P. Extranodal B Cell Lymphoma Spreading from Skin to Oral Cavity. Int J Head Neck Surg 2013;4(3):126-128.